ID   BAX1B_CHICK             Reviewed;         247 AA.
AC   Q9DED6;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Homeobox protein BarH-like 1b;
DE   AltName: Full=Bar class homeoprotein Barx1b;
GN   Name=BARX1B;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11359793; DOI=10.1074/jbc.m101127200;
RA   Nakamura M., Nishida W., Mori S., Hiwada K., Hayashi K., Sobue K.;
RT   "Transcriptional activation of beta-tropomyosin mediated by serum response
RT   factor and a novel Barx homologue, Barx1b, in smooth muscle cells.";
RL   J. Biol. Chem. 276:18313-18320(2001).
CC   -!- FUNCTION: Transcription factor which is involved with the serum
CC       response factor (SRF) in the smooth muscle cell-specific transcription
CC       of the beta-tropomyosin gene in the upper digestive organs and their
CC       attached arteries.
CC   -!- SUBUNIT: Interacts with serum response factor (SRF).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in smooth muscle cells of the upper
CC       digestive organs and their attached arteries and to craniofacial
CC       structures.
CC   -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR   EMBL; AB044371; BAB18919.1; -; mRNA.
DR   RefSeq; NP_989524.1; NM_204193.1.
DR   AlphaFoldDB; Q9DED6; -.
DR   SMR; Q9DED6; -.
DR   STRING; 9031.ENSGALP00000008226; -.
DR   Ensembl; ENSGALT00000071813; ENSGALP00000054219; ENSGALG00000035557.
DR   GeneID; 374017; -.
DR   KEGG; gga:374017; -.
DR   CTD; 56033; -.
DR   VEuPathDB; HostDB:geneid_374017; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000160218; -.
DR   InParanoid; Q9DED6; -.
DR   OMA; LGAHYYP; -.
DR   OrthoDB; 1382174at2759; -.
DR   PhylomeDB; Q9DED6; -.
DR   PRO; PR:Q9DED6; -.
DR   Proteomes; UP000000539; Chromosome 12.
DR   Bgee; ENSGALG00000035557; Expressed in spleen and 1 other tissue.
DR   ExpressionAtlas; Q9DED6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..247
FT                   /note="Homeobox protein BarH-like 1b"
FT                   /id="PRO_0000048837"
FT   DNA_BIND        135..194
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          118..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  27027 MW;  A72EFFA192F8624F CRC64;
     MQHPLELGAA HYFPAEAFPD HRSHRYRSFM IEEILTDPPD AKGTAPPGEL LKFGVQALLS
     ARPYHSHLAV LKAEPAAVFK FPLAPLGCSG LGSALLAAGS GLQGGSASPH LPLELHLRGK
     LEPGGPETGS KAKKGRRSRT VFTELQLMGL EKRFEKQKYL STPDRIDLAE SLGLSQLQVK
     TWYQNRRMKW KKIVLQGGGL ESPTKPKGRP KKNSIPSSEQ LSEQERARDA EKPPESLGSP
     AEVSQEE