RS8_DROME
ID RS8_DROME Reviewed; 208 AA.
AC Q8MLY8; Q9VAF1;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=40S ribosomal protein S8;
GN Name=RpS8; ORFNames=CG7808;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC {ECO:0000305}.
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DR EMBL; AE014297; AAN14192.1; -; Genomic_DNA.
DR EMBL; AY118424; AAM48453.1; -; mRNA.
DR EMBL; AY118446; AAM48475.1; -; mRNA.
DR RefSeq; NP_001247362.1; NM_001260433.3.
DR RefSeq; NP_001287596.1; NM_001300667.1.
DR RefSeq; NP_001287597.1; NM_001300668.1.
DR RefSeq; NP_651740.1; NM_143483.3.
DR PDB; 4V6W; EM; 6.00 A; AI=1-208.
DR PDB; 6XU6; EM; 3.50 A; AI=2-208.
DR PDB; 6XU7; EM; 4.90 A; AI=2-208.
DR PDB; 6XU8; EM; 3.00 A; AI=2-208.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; Q8MLY8; -.
DR SMR; Q8MLY8; -.
DR BioGRID; 68391; 122.
DR IntAct; Q8MLY8; 5.
DR MINT; Q8MLY8; -.
DR STRING; 7227.FBpp0099686; -.
DR PaxDb; Q8MLY8; -.
DR PRIDE; Q8MLY8; -.
DR EnsemblMetazoa; FBtr0085489; FBpp0099686; FBgn0039713.
DR EnsemblMetazoa; FBtr0310274; FBpp0301957; FBgn0039713.
DR EnsemblMetazoa; FBtr0346158; FBpp0311986; FBgn0039713.
DR EnsemblMetazoa; FBtr0346159; FBpp0311987; FBgn0039713.
DR GeneID; 43532; -.
DR KEGG; dme:Dmel_CG7808; -.
DR CTD; 6202; -.
DR FlyBase; FBgn0039713; RpS8.
DR VEuPathDB; VectorBase:FBgn0039713; -.
DR eggNOG; KOG3283; Eukaryota.
DR GeneTree; ENSGT00390000012433; -.
DR HOGENOM; CLU_080597_1_1_1; -.
DR InParanoid; Q8MLY8; -.
DR OMA; VGRCDGY; -.
DR OrthoDB; 1278610at2759; -.
DR PhylomeDB; Q8MLY8; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DME-72649; Translation initiation complex formation.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DME-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 43532; 0 hits in 1 CRISPR screen.
DR ChiTaRS; RpS8; fly.
DR GenomeRNAi; 43532; -.
DR PRO; PR:Q8MLY8; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039713; Expressed in seminal fluid secreting gland and 14 other tissues.
DR ExpressionAtlas; Q8MLY8; baseline and differential.
DR Genevisible; Q8MLY8; DM.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:FlyBase.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; TAS:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0006412; P:translation; ISS:FlyBase.
DR Gene3D; 1.10.168.20; -; 1.
DR InterPro; IPR042563; Ribosomal_protein_S8e_euk.
DR InterPro; IPR001047; Ribosomal_S8e.
DR InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR InterPro; IPR018283; Ribosomal_S8e_CS.
DR PANTHER; PTHR10394; PTHR10394; 1.
DR Pfam; PF01201; Ribosomal_S8e; 1.
DR TIGRFAMs; TIGR00307; eS8; 1.
DR PROSITE; PS01193; RIBOSOMAL_S8E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..208
FT /note="40S ribosomal protein S8"
FT /id="PRO_0000122249"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 208 AA; 23759 MW; EC96C28BCCF6FE0E CRC64;
MGISRDSAHK RRATGGKRKS LRKKRKFELG RPAANTKLGS GRVHKVRTRG GNTKLRALRL
ETGNFAWASE GVARKTRIAD VVYNASNNEL VRTKTLVKNS IVVIDATPFR QWYEAHYVLP
LGRKRNPKHA QKEDENDVLT KKRSEKVMKK YLERQKYGKV EQALEDQFTS GRILACISSR
PGQCGRSDGY ILEGKELEFY LKKIKSKK
