ABCC1_DICDI
ID ABCC1_DICDI Reviewed; 1359 AA.
AC Q8T6H8; Q54V81;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=ABC transporter C family member 1;
DE AltName: Full=ABC transporter ABCC.1;
GN Name=abcC1; ORFNames=DDB_G0280541;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AF474333; AAL85704.1; -; Genomic_DNA.
DR EMBL; AAFI02000037; EAL67072.1; -; Genomic_DNA.
DR RefSeq; XP_641050.1; XM_635958.1.
DR AlphaFoldDB; Q8T6H8; -.
DR SMR; Q8T6H8; -.
DR STRING; 44689.DDB0215360; -.
DR PaxDb; Q8T6H8; -.
DR EnsemblProtists; EAL67072; EAL67072; DDB_G0280541.
DR GeneID; 8622608; -.
DR KEGG; ddi:DDB_G0280541; -.
DR dictyBase; DDB_G0280541; abcC1.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_3_1; -.
DR InParanoid; Q8T6H8; -.
DR OMA; PPYAWPS; -.
DR PhylomeDB; Q8T6H8; -.
DR PRO; PR:Q8T6H8; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1359
FT /note="ABC transporter C family member 1"
FT /id="PRO_0000363847"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 773..793
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 819..839
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 884..904
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 906..926
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 999..1021
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 111..394
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 470..690
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 763..1061
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1116..1350
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 409..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1073..1102
FT /evidence="ECO:0000255"
FT COMPBIAS 436..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 502..509
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1150..1157
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1359 AA; 155511 MW; F746150C99C7578A CRC64;
MLKNLRNKIK EKLTYSLLSS QEFDNNKDYY QQPCPEDNAN LWSRLTFGWA QRMLISGYFN
GPLEMSDIND LPKDIKVQSS IQLLNNINLN KNNNSRWPLI KHFYKQFLYR NKLTIFLQIL
TNILSILSPL SLKYFIQFIQ STNKERSFLA GIGYCILLLI ASFSYTFSQQ LLMWFAMKSS
LEIKGCLSIK VYEKTLKLTT CGGKNYNPGS IMNLLSVDVG IISNFFWIEH MGIFAFSSQM
IGLLALLCWV IGWSGLVGFA IMVITFPINT YIGSKIGKNL KESMGYSDKR TNLTSEFING
IRFLKMYAWE KLFLDRIEEQ RSLQLKYLYK RMIFWIFAEM MKQAVNAIVL VLTFIVYSIN
NEITLEVAFT TISIFVSLRI PLLRLPNSIQ QLQSLIPIAK RVEDFLKSPE IQQNHSSNRE
EEEEDEYDDD INSDGDISIH NGSFNWNQVD SNGSGNGNGN QQQQQQQQQQ QQQQQQQQQQ
QSYTLNNINF KAPAGKLTII CGVVGSGKTS LVSGLIGEIY KVSGRVNTPN KISFTTQQSF
LLSTSLRENI LFGNEMNLER YKKVIEACCL APDLLQLAAK DLTEIGERGI NLSGGQKQRI
SLARALYANS DCYILDEPLS AVDPEVATHL FNHCIQGMMN DKTRILITHQ LQFIPSADHI
VVVDNGKLVQ GTYSELKSKG IDFESIMKTK KLNIDNQQQQ QQHEKENDIV LSDEDSNNSI
KNNNNISNLI DIDEVISDEN DSNLIERSKL LVDEDRNEGS VNLRVYKEYF KHGSSIPLFI
MTCIVYMISQ IIYQMSDFWL STWSQRSIPD KTDKYYISIY LLFIVGFIIF LVIRYFMMAH
VTFSASKNLH QSLLKSVGFA SCQFFDTNPS GRILNRFSKD ISDVDLLLFD LFSDVLYCGS
TVLVSIGIMI YISPLIIIPF LLLIGIYYFI QRLYTESSRE LKRLEAISRS PIFSLLQESF
NGLVTIRSYK QQNKFISMMQ DRINTNHRLS YYGFSVHRWV AVRLEFISSI VVFLAAFFSL
FNSNAGFSVL SVTTALGMCS YLNWTVRQMV ELEVKMNSVE RIESYLNIPK EGNSKINFFR
NEQQEEEEEE EEEFDFDNDD YDGFKLSKKW LTKGEIEFRN VEIKYGHSGE SSLKNFTLKI
NQKDHIGIVG RTGAGKSTIG NGLFRMVECS KGSILIDGVD ISKIGLHELR SSLGIVPQDP
FIFSGTIRLN IDPFNKYTDS EIWVALEKVK LKSTISSMPL KLETMIEEGG DGLSFGQKQL
LCLSRTILKN SKVVLMDEAT SGIDYVTSDL IKQTINNCFK NCTMLTIAHR LDTIIDSTKI
AVIDKGKLIE YDTPNNLIEN QESRFSKLVK HHHNLFKEK
