ID   BBCI_BAUBA              Reviewed;         164 AA.
AC   P83051;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Kunitz-type proteinase inhibitor BbCI;
OS   Bauhinia bauhinioides (Perlebia bauhinoides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Cercidoideae; Cercideae; Bauhiniinae;
OC   Bauhinia.
OX   NCBI_TaxID=166014 {ECO:0000305};
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Seed;
RX   PubMed=11517940; DOI=10.1515/bc.2001.103;
RA   de Oliveira C., Santana L.A., Carmona A.K., Cezari M.H., Sampaio M.U.,
RA   Sampaio C.A.M., Oliva M.L.V.;
RT   "Structure of cruzipain/cruzain inhibitors isolated from Bauhinia
RT   bauhinioides seeds.";
RL   Biol. Chem. 382:847-852(2001).
CC   -!- FUNCTION: Inhibits T.cruzi cruzipain. {ECO:0000269|PubMed:11517940}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I3 (leguminous Kunitz-
CC       type inhibitor) family. {ECO:0000305}.
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DR   PDB; 2GZB; X-ray; 1.70 A; A/B=1-164.
DR   PDBsum; 2GZB; -.
DR   AlphaFoldDB; P83051; -.
DR   SMR; P83051; -.
DR   EvolutionaryTrace; P83051; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011065; Kunitz_inhibitor_STI-like_sf.
DR   InterPro; IPR002160; Prot_inh_Kunz-lg.
DR   PANTHER; PTHR33107; PTHR33107; 1.
DR   Pfam; PF00197; Kunitz_legume; 1.
DR   SMART; SM00452; STI; 1.
DR   SUPFAM; SSF50386; SSF50386; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Protease inhibitor; Secreted;
KW   Thiol protease inhibitor.
FT   CHAIN           1..164
FT                   /note="Kunitz-type proteinase inhibitor BbCI"
FT                   /id="PRO_0000083294"
FT   STRAND          12..14
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          18..25
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          28..33
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          43..47
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          50..52
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          54..59
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          61..63
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          73..79
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          86..92
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   TURN            93..95
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          96..103
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          110..116
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          119..124
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          133..140
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          143..151
FT                   /evidence="ECO:0007829|PDB:2GZB"
FT   STRAND          156..160
FT                   /evidence="ECO:0007829|PDB:2GZB"
SQ   SEQUENCE   164 AA;  18033 MW;  D55F06DE01646423 CRC64;
     SVILDTKGEP VSNAADAYYL VPVSHGEGGL ALAKVGNEAE PKAVVLDPHH RPGLTVRFET
     PLAIAIITES FFLNIKFVPS SSDSEVWDVS KQYPIGLAVK VTDTKSFVGP FRVEKEGEGY
     KIVYYPDRGQ TGLDIGLVHR NDKYYLAATE GEPFVFKIRK ATYE