ABCC2_DICDI
ID ABCC2_DICDI Reviewed; 1384 AA.
AC Q54VJ0; Q8T6H7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=ABC transporter C family member 2;
DE AltName: Full=ABC transporter ABCC.2;
GN Name=abcC2; ORFNames=DDB_G0280055;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL85705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF474334; AAL85705.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000035; EAL67254.1; -; Genomic_DNA.
DR RefSeq; XP_641365.1; XM_636273.1.
DR AlphaFoldDB; Q54VJ0; -.
DR SMR; Q54VJ0; -.
DR STRING; 44689.DDB0220024; -.
DR PaxDb; Q54VJ0; -.
DR EnsemblProtists; EAL67254; EAL67254; DDB_G0280055.
DR GeneID; 8622499; -.
DR KEGG; ddi:DDB_G0280055; -.
DR dictyBase; DDB_G0280055; abcC2.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_1_1; -.
DR InParanoid; Q54VJ0; -.
DR OMA; GKRINAF; -.
DR PhylomeDB; Q54VJ0; -.
DR PRO; PR:Q54VJ0; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1384
FT /note="ABC transporter C family member 2"
FT /id="PRO_0000363848"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 813..833
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 852..872
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 941..961
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1036..1056
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1061..1081
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 104..388
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 505..724
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 814..1093
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1137..1371
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 729..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 537..544
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1171..1178
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1384 AA; 157060 MW; 11EADB8B2DC421AE CRC64;
MIKNLKQKIK NRFSYSLLSE DDNTDYFSKP CPEDNATLWQ RFTFGWTERM LMTGYFNGPL
EMKDVSDLPD RNKVNITAPF LDTIDYNSKY PLIKQIYKEF VSRNKISVAT KIFVAIVSIL
SPLCLKYFIY YIKLDESQKT FKFGFLLCVL LFLSSLSLTL SQQYGYWFGL QTSLHARGAI
TQKIFEKTLR LSNQAKRLYN SGTIMNIISV DVGTFSDFFW NNHIEIFVFP FQILALLILL
CWIVGLSGLV GFGVMVVSIP LCTFLSTKIA KNLRISLGYA DTRCNLTSEF INGIRFLKLY
AWEQLFLDRI EEQRTLQLKY LYRRAIYWIL DRMITQVTSA LVLVATFSTY ALTGNQMTLE
VAFTAMTIFV NLRRPLEMLP EAIHRALSLI PSSKRIENFL QSPEIQDQPF LEQYSNNKLS
IRNNNNNNNN VSSTSSIASS ASSNELFDVK INNGTFDWNE IDDLDSGMII NDVRGFAISS
DINDMDEMIL GDEKVGKSND TNNGIEYDGA VQPSSSSYVL NNINFIAPAG KLTVICGIVG
SGKTSLVSGL IGEIYRVSGS VNIPNNISFT TQQPFLLSTS LRDNILFGKP MNMERYKKVI
DACCLTPDLL QLAAKDLTEI GERGINLSGG QKQRISLARA LYSDSDCFIL DEPLSAVDPE
VASHLFDHCI QGMMKDKTRI LVTHQLQFIP SADHIIVVDN GVLTQGTYSE LKEKGIDFES
IMKTKKLNID ENDQSSTSTT DKKSSTSSSS SELKKSTSLL NSTKELDINT IISEKNDPNL
IEKAKLLVKE DRNEGEVGFE VYRQYFRHGS LNLFFLTCAL YFISQIIFQL SDFWLTIWTN
DETNQHDDKY YILYYCIFIG AFIVFLVVRY FMMASITFAA SKKLHSELLN SVAFASCQFF
DTNPSGRILN RFSKDISDID LILMENFSDV LQCGSTVVVA LFMMIYITPL ISIPFAILVV
VYYVIQKLYR ASSVELKRME SITRSPVFSL LAEAYNGLVT IRCYQQQKRF IEMMQNHINI
NLRLFFYSFS VHRWVGIRLE FITALIVFFT AFSSLFSSNT GFSVLAVTTA LGICSYLNWT
IRQMTELEVK MNSVERVESY IKTPREGIRH TSEFEDEIDI DGEIEMDFTK WPSRGEVEFK
NVEIKYRPTA DPSLKNISFK INAKDHIGVV GRTGAGKSTV GISLFRMVEC SKGSIFIDGV
DISKVGLHEL RDALGIVPQD PFIFSGSIRM NIDPFNKYTD DEIWTALEKV KLKDAISSMP
LKLESGVQEN GDGLSFGQKQ LLCLSRTILK NSKVVLMDEA TSGIDYVTAA LLKQTIDENF
NDCTMLTIAH RLDTIIDSTK IAVIDKGELV EYDTPMNLIK TEGSRFKKLV KYQTDFYEES
QKKF
