RS8_RAT
ID RS8_RAT Reviewed; 208 AA.
AC P62243; P09058;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=40S ribosomal protein S8;
GN Name=Rps8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 205-208.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=3684599; DOI=10.1093/nar/15.22.9451;
RA Chan Y.-L., Lin A., Paz V., Wool I.G.;
RT "The primary structure of rat ribosomal protein S8.";
RL Nucleic Acids Res. 15:9451-9459(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Liver;
RX PubMed=398910; DOI=10.1002/jss.400120403;
RA Wittmann-Liebold B., Geissler A.W., Lin A., Wool I.G.;
RT "Sequence of the amino-terminal region of rat liver ribosomal proteins S4,
RT S6, S8, L6, L7a, L18, L27, L30, L37, L37a, and L39.";
RL J. Supramol. Struct. 12:425-433(1979).
CC -!- SUBUNIT: Identified in a IGF2BP1-dependent mRNP granule complex
CC containing untranslated mRNAs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
CC {ECO:0000250|UniProtKB:P62241}; Lipid-anchor
CC {ECO:0000250|UniProtKB:P62241}. Note=Localized in cytoplasmic mRNP
CC granules containing untranslated mRNAs. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC {ECO:0000305}.
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DR EMBL; X06423; CAA29732.1; -; mRNA.
DR EMBL; BC082802; AAH82802.1; -; mRNA.
DR PIR; S01609; R3RT8.
DR RefSeq; NP_113894.1; NM_031706.1.
DR AlphaFoldDB; P62243; -.
DR SMR; P62243; -.
DR BioGRID; 249257; 7.
DR IntAct; P62243; 7.
DR STRING; 10116.ENSRNOP00000025796; -.
DR iPTMnet; P62243; -.
DR PhosphoSitePlus; P62243; -.
DR jPOST; P62243; -.
DR PaxDb; P62243; -.
DR PRIDE; P62243; -.
DR GeneID; 65136; -.
DR KEGG; rno:65136; -.
DR UCSC; RGD:61910; rat.
DR CTD; 6202; -.
DR RGD; 61910; Rps8.
DR VEuPathDB; HostDB:ENSRNOG00000054626; -.
DR eggNOG; KOG3283; Eukaryota.
DR HOGENOM; CLU_080597_1_1_1; -.
DR InParanoid; P62243; -.
DR OMA; VGRCDGY; -.
DR OrthoDB; 1278610at2759; -.
DR PhylomeDB; P62243; -.
DR TreeFam; TF300041; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62243; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000054626; Expressed in ovary and 19 other tissues.
DR ExpressionAtlas; P62243; baseline and differential.
DR Genevisible; P62243; RN.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 1.10.168.20; -; 1.
DR InterPro; IPR042563; Ribosomal_protein_S8e_euk.
DR InterPro; IPR001047; Ribosomal_S8e.
DR InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR InterPro; IPR018283; Ribosomal_S8e_CS.
DR PANTHER; PTHR10394; PTHR10394; 1.
DR Pfam; PF01201; Ribosomal_S8e; 1.
DR TIGRFAMs; TIGR00307; eS8; 1.
DR PROSITE; PS01193; RIBOSOMAL_S8E; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62241"
FT CHAIN 2..208
FT /note="40S ribosomal protein S8"
FT /id="PRO_0000122242"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 37
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62242"
FT MOD_RES 128
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62242"
FT MOD_RES 130
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P62241"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62241"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:P62241"
FT CROSSLNK 170
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62241"
FT CROSSLNK 193
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62241"
SQ SEQUENCE 208 AA; 24205 MW; 407FDF59171F7422 CRC64;
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL
DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP
LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS LLEEQFQQGK LLACIASRPG
QCGRADGYVL EGKELEFYLR KIKARKGK
