ABCC5_DICDI
ID ABCC5_DICDI Reviewed; 1460 AA.
AC Q54LE6; Q8T6H4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=ABC transporter C family member 5;
DE AltName: Full=ABC transporter ABCC.5;
GN Name=abcC5; ORFNames=DDB_G0286559;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 613-1460, AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000089; EAL64035.1; -; Genomic_DNA.
DR EMBL; AF474337; AAL85708.1; -; Genomic_DNA.
DR RefSeq; XP_637615.1; XM_632523.1.
DR AlphaFoldDB; Q54LE6; -.
DR SMR; Q54LE6; -.
DR STRING; 44689.DDB0220025; -.
DR PaxDb; Q54LE6; -.
DR EnsemblProtists; EAL64035; EAL64035; DDB_G0286559.
DR GeneID; 8625755; -.
DR KEGG; ddi:DDB_G0286559; -.
DR dictyBase; DDB_G0286559; abcC5.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_6_1; -.
DR InParanoid; Q54LE6; -.
DR OMA; PWYLLNT; -.
DR PhylomeDB; Q54LE6; -.
DR Reactome; R-DDI-189483; Heme degradation.
DR Reactome; R-DDI-2142691; Synthesis of Leukotrienes (LT) and Eoxins (EX).
DR Reactome; R-DDI-2142850; Hyaluronan biosynthesis and export.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-9707564; Cytoprotection by HMOX1.
DR Reactome; R-DDI-9748787; Azathioprine ADME.
DR Reactome; R-DDI-9749641; Aspirin ADME.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR Reactome; R-DDI-9754706; Atorvastatin ADME.
DR Reactome; R-DDI-9758890; Transport of RCbl within the body.
DR PRO; PR:Q54LE6; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1460
FT /note="ABC transporter C family member 5"
FT /id="PRO_0000363850"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 842..862
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 922..942
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1014..1034
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1108..1128
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 196..482
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 560..783
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 853..1166
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1210..1444
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 593..600
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1244..1251
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 613..615
FT /note="ENN -> REY (in Ref. 2; AAL85708)"
FT /evidence="ECO:0000305"
FT CONFLICT 839
FT /note="K -> N (in Ref. 2; AAL85708)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1460 AA; 165282 MW; 496690ABE21E2F24 CRC64;
MKYNNLENDD SDIHNNNNNN ESEGDSLIEL EEINLEGNNN NDINNNNNIN NNNDSLDYEN
NKGSKKKNNK KYVILNEEED INDKKVENGE NETSSFTYGH DNEFKDLPLP KKGFGGLKSL
EENANFLSSM TYLWADKFVL YCFKNILQLD EIWELASYDK SSYLFDIMDK NWQNELKNSK
KPNFMKAAFK SFGKHFALSW VHFGLNVISQ FIGPIFLKKI VSFVIQYREN PGSVDPNLGY
YYALILFVNS MLGSIFLYQS NMITSRTGNR LKSLIVLYVY KKSLKLTNSS RSKKSNGEIV
NLMSNDAQRL LELFQMVNTL IFAVPMIIVS MILLYDCVGW PSFVALLVMG ISLPYSLNRG
SQLSIYRRKL VGFTDQRIKV VNEMFQAIKT IKLYAWEDYF SQKMMSKRGE EIKFLTQFVR
FRYSLIVVVQ SIPTIISIFM FTVYYLVNSK LPADKIFAAV AYLNIIRVPF TFLPYGYNIY
IQFKVSIERV VNFLNMDEIN QGDDKNNEIN VNVCDQQKQQ QTDIGIYMDN TTFSWAIKPQ
TNPPPPRTTP SNDKSSPSGN NSNNEKKEVQ VSFSLKNTSC QVKEKGSLLM VIGPVGSGKS
SFCQALLGEM ELENNGSLRV VGSIAYVSQS AWIMNASLKD NILFGKEYNK ERYEMVLNCC
ALLPDLALFP QGDLIEIGER GINLSGGQKQ RVAIARAVYS DSDIYILDDI LSAVDAHVGK
HLFYNCIKGI LKEKIVVLAT NQLNYCPYST QTLILKTGGE VEQYDTFENI ISTINSAYGN
SSLFSELLKQ YAHMAGDSDK DSDEIVDDEM IKSKENNNDL YDGKLTTIEE REEGSVSFKH
YMYYVTAGGG FLFLIALLGY CIDTSTSTFT NWWLSNWSSK HTSTGINNNN SSSSNSISSS
SSYIIDSLSS LNINEDGDIE NAGEFLGVFI AIGVLTVLLI IVRTIVFFEY SIRATTEIHK
RLFWSILRAP MWFFDTVPLG RILNRFTRDT DIVDMLLTNS LNQFLNFSTN CIAILVIISI
ATPWLLLPMT PIIILFYFIQ YFYRRTSIQI QRIESITRSP IFSHFAETLN GVITLRAFRK
MGENVLKNQA LLDDNNKCYL TLQAMNQWLG LRLSVLGNLI TLLSCIFITV DRSSIAIASV
GLSISYTLSL TTNLNKATQQ LAELETKMNS IERISYYTEN VPQEPDQIIE SNRPPMGWPS
LTNSNHTPPI IFENVVMSYR QGLPAVLKGI SFEIKAGEKI GICGRTGSGK SSLLLALFRI
VELSSGRIII DGLDISKIGL KDLRSQLAII PQEPVMFTGT LRSNLDSLSE HTDSELWDVL
KEIQLYEHVK KVSVADEGLD LRVNDNWSQG QKQLIGLGRA LLKKPKILVC DEATASVDSL
SDELIQRIIR EKFKDAIILT IAHRLNTIVE SDRIMVLDSG SIVEFNKPSI LAQNENSLFN
WLIDETGTQN SQYLRSLIKH
