BBEX_BACSU
ID BBEX_BACSU Reviewed; 402 AA.
AC O31762; O31763;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Bacillibactin exporter;
GN Name=ymfD; Synonyms=ymfE; OrderedLocusNames=BSU16825;
GN ORFNames=BSU16820, BSU16830;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [3]
RP FUNCTION AS AN EXPORTER, AND INDUCTION.
RC STRAIN=ATCC 21332 / IAM 1213;
RX PubMed=18502870; DOI=10.1128/jb.00464-08;
RA Miethke M., Schmidt S., Marahiel M.A.;
RT "The major facilitator superfamily-type transporter YmfE and the multidrug-
RT efflux activator Mta mediate bacillibactin secretion in Bacillus
RT subtilis.";
RL J. Bacteriol. 190:5143-5152(2008).
CC -!- FUNCTION: Involved in secretion of bacillibactin.
CC {ECO:0000269|PubMed:18502870}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Induced by mta. {ECO:0000269|PubMed:18502870}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AL009126; CAB13555.2; -; Genomic_DNA.
DR PIR; C69885; C69885.
DR PIR; D69885; D69885.
DR RefSeq; NP_389564.2; NC_000964.3.
DR RefSeq; WP_010886509.1; NC_000964.3.
DR AlphaFoldDB; O31762; -.
DR SMR; O31762; -.
DR STRING; 224308.BSU16825; -.
DR TCDB; 2.A.1.32.2; the major facilitator superfamily (mfs).
DR PRIDE; O31762; -.
DR EnsemblBacteria; CAB13555; CAB13555; BSU_16825.
DR GeneID; 939662; -.
DR KEGG; bsu:BSU16825; -.
DR PATRIC; fig|224308.43.peg.1779; -.
DR eggNOG; COG2814; Bacteria.
DR InParanoid; O31762; -.
DR OMA; LHHFWWG; -.
DR PhylomeDB; O31762; -.
DR BioCyc; BSUB:BSU16825-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 2.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..402
FT /note="Bacillibactin exporter"
FT /id="PRO_0000349884"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 402 AA; 43675 MW; 990AE8FCB54F441F CRC64;
MKNIIALSSV PLVMTLGNSM LIPVLPMMEK KLSVTSFQVS LIITVYSVVA IICIPIAGYL
SDRFGRKKIL LPCLLIAGLG GAVAAFASTY MKNPYAMILA GRVLQGIGSA GAAPIVMPFI
GDLFKGDDEK VSAGLGDIET ANTSGKVLSP ILGALLASWY WFVPFWFIPF FCLISFLLVL
FLVAKPEEDE DAPAVSEFIK SVKKIFKQDG RWLYTVFIIG CVIMFLLFGV LFYLSDTLEN
KYAIDGVAKG GLLAIPLLFL STSSFIAGKK IGKDKGRMKF CVVTGMILLT LSFIALWWNH
SFYFLFVFLS FGGIGIGMAL PALDALITEG IESEQCGTIS SFYNSMRFIG VALGPPVFAA
LMSNANWIIF ILSAFCSIVS LFLVLFTVDA KKSEEEKNLG TV
