ABCC6_DICDI
ID ABCC6_DICDI Reviewed; 1351 AA.
AC Q8T6H3; Q54K23;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=ABC transporter C family member 6;
DE AltName: Full=ABC transporter ABCC.6;
GN Name=abcC6; ORFNames=DDB_G0287593;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AF474338; AAL85709.1; -; Genomic_DNA.
DR EMBL; AAFI02000103; EAL63605.1; -; Genomic_DNA.
DR RefSeq; XP_637141.1; XM_632049.1.
DR AlphaFoldDB; Q8T6H3; -.
DR SMR; Q8T6H3; -.
DR STRING; 44689.DDB0219975; -.
DR PaxDb; Q8T6H3; -.
DR PRIDE; Q8T6H3; -.
DR EnsemblProtists; EAL63605; EAL63605; DDB_G0287593.
DR GeneID; 8626236; -.
DR KEGG; ddi:DDB_G0287593; -.
DR dictyBase; DDB_G0287593; abcC6.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_3_1; -.
DR InParanoid; Q8T6H3; -.
DR OMA; KMEDPSN; -.
DR PhylomeDB; Q8T6H3; -.
DR PRO; PR:Q8T6H3; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1351
FT /note="ABC transporter C family member 6"
FT /id="PRO_0000363851"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 771..791
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 815..835
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 977..999
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1002..1022
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1025..1045
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 112..397
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 474..700
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 777..1060
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1101..1336
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT COILED 701..734
FT /evidence="ECO:0000255"
FT BINDING 510..517
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1135..1142
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1351 AA; 154308 MW; FB3E88A0D05BA25A CRC64;
MFTKILKKFF SSYEKLKDNE DENEPSSNST NNFYKTCPED NSSKWSKISF NWVTKLIMKG
YLKESLEMND IYDLPELNKV QTTSKLLEDI DLSNNSNYTL IKHIYKKFLP KNKYALVSNL
FIIIFTFLSP ICLKFLINYI SIQDENEKSI LKGILLCCLL CLCVLGQSIS QELFYWFGIK
NGFDVRGALA AKIFEKTLKL SNASRKEYKS GKIMNIMSID VANISEYFWT HHINIVSHFI
QILSLVGLLC YVVGPSGLVG FGVMVIALPI NAMLCAKSSN YLEKSLEYSD SRTNLTSELI
TNIRPFKMYA WENFFINKID GQRKQELKNI FLRIFYSILD HMMIETNATL VLVSTFATYS
LNGNTMSLDV TFTAMTIFSK LEVPLIRLPY DIFKAIGLIP SVKRVQNFLK SSESLKYNKN
FKNENQKITT TKENNNQHGQ DNDIIVENCT FQWNEPENNN IFELNYGDNE EEENQDESIN
KKENDNEEFN YKLKDINLIV PKGKLTMICG VVGSGKTSLI FGLIGEIYKL NGSVSGVPNN
ISFTSQQPFL LSASLRENIL FGNEFDIERY KKVIESTALT KDIVNLAGLD LTEIGERGIN
LSGGQKQRIS LARALYANSD CFIFDEPLSA VDPEVASHLF DHCIQGELMR NKTRILVTHQ
LQFIPYADHI IVLNSNGQLI QGTYQELNEK GIDFKSILKT KEIKKNVENE TDSEELIKNE
IEIENEIIDV NNAISDKNDP NLIEKAKLLV KEDKNEGEVE FNVYKKYFSY GSSGVTLFIT
ISLFFVGQAI FKVSDFWLTI WTERSIEGKS DSFYIGYYLL IFGTFVVILM IRILLLCRIT
FNVGKNLHSA LLKSVTYASC RFFDTNPSGR ILNRFSKDTS DIDIHMFDIL TEVSMCFSEL
TIGLISIVFI IPIMVIPLII LSIAYYILQR LYRPSARELN RWESITVSPI FSLLQECYNG
LLTIRTYKQE SRFIKEMFDN ININLGCFFY SFAVHRWVSM RLEVMGWIMV FFTSLIATLF
ISNNGLAALS VTTALSLNGY LSWGIRRIVD LEVKMNSFQR IQSYIEIPKE GNKLVSTNSN
EVDNHTIKDA DLVNWPNKGI IEFKNVEIKY RPNSEPNLKD LSFKVQSSEK IGIVGRTGAG
KTTIASSLFR MVECSKGLIL IDGIDISKVQ LQKLRSSIGI VPQDPFIFTG TIRSNIDPFN
EFTDFEIWES VEKVKLKDAI NSMPLKLETA LQENGDNGFS YGQKQLLCLC RTILKNFKII
LMDEATSSID YHTAQLIKQT IQENFKDCTT LTIAHRLETI IDCNKIAVID SGQLIEFDTP
SNLMNIPNSK FNKLIKSQTD YNNNEKTIIN K
