ABCC7_DICDI
ID ABCC7_DICDI Reviewed; 1328 AA.
AC Q54EK2; Q8T6H2;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=ABC transporter C family member 7;
DE AltName: Full=ABC transporter ABCC.7;
GN Name=abcC7; ORFNames=DDB_G0291243;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-1328, AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL85710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AAFI02000177; EAL61605.1; -; Genomic_DNA.
DR EMBL; AF474339; AAL85710.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_635238.1; XM_630146.1.
DR AlphaFoldDB; Q54EK2; -.
DR SMR; Q54EK2; -.
DR STRING; 44689.DDB0201630; -.
DR PaxDb; Q54EK2; -.
DR EnsemblProtists; EAL61605; EAL61605; DDB_G0291243.
DR GeneID; 8628184; -.
DR KEGG; ddi:DDB_G0291243; -.
DR dictyBase; DDB_G0291243; abcC7.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_3_1; -.
DR InParanoid; Q54EK2; -.
DR OMA; VAIFNVM; -.
DR PhylomeDB; Q54EK2; -.
DR PRO; PR:Q54EK2; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1328
FT /note="ABC transporter C family member 7"
FT /id="PRO_0000363852"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 762..782
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 802..822
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 894..914
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 988..1008
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1014..1034
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 104..389
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 457..678
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 765..1046
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1083..1316
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 684..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 490..497
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1117..1124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1328 AA; 152024 MW; 0B641C07B1DCA367 CRC64;
MKNKKKIKNK ISYSLLEREL MGSRENEIAP EDCASFLSRI TYSWTQKMLI YGYFNTLQLK
DVPDLPESIK VENTTPILDE FKFKKNEKFG LVWFIYKRFV MVRHKTSIIV QIFSAIVSVL
SPLCLRAFIL YVQREPSEKS FLVGLFYAVL VLMGALFLSI SLQHTYWYTM KCGLEVKGAL
TSKIYSKTLK LSNYGKRLYS SGTILNLISS DCQNFADYFW IDYLILLVAP IQIIALLALL
CWTIGYSGLV GFLIMILSLP LSTFLSSKVS KYQLLSLKYS DKRCNLISEM INGIYLLKLY
NWELFFINRI EKQRKQQLIN LYKRMAFWAL DKMVVQISSA LVLVSSFTVY TLIANKSITY
EVAFTSISIF SNLREPCELL PQAIQRLLSL LPSSDRICKF LYETSEIIEN LSTITTTNGT
NQDILITNGT FDWNDNNKNI NVGVDSQENK NDDDDMIELV NNDSIETTTS YVLDDINFIA
PAGKLTIICG VVGSGKSSLI NGLIGEIYKV SGQVTIPNTV SFTNQQPFLV NSTLRENILF
GLPMDMDRYK KVLESCSLLT DLQSMPGKDL TEIGERGINL SGGQKQRINL ARALYSNSDC
YILDEPLSAV DPQVATHLFN HCIQGELMNN KTRILVTHQL QFIPSADHIV VLENGILTQG
TYQELKDKFD FESIMKTKKL NLELNNSNNN NNNNNNKEEE EDVENLEKEQ QQQVINVNDV
ISNEFESKND ELNSKLLVNE ERETGSVELN IYKMYIKYGS SFIFFFTMIM MYIISQLLFL
LFDYWLTIWS DEKKNKNGTK GDSFYILYYL LLVGLFSVFL GIRYFMILHF TNSSSKNLHD
KLLKSIGYAS CQFFDINSSG RINNRFTKDI AEVDLILMVL SDALYCGSTV LVAVLMMIVI
NPLIVFPFLL LALFYYLVQK LYRSSSLELK RLENISRSPI FSILSESFNG LITIRSFRQQ
SRFIKRMQDS INVNLRLFYY NFSAHRWIGI KIEIISSAAV FLSAFFSLFN SNTGLSVLAV
TTSLSLTGYL NWCIRQYIEF SMKMSSVERI ENYINQPREG DTMNVDMELE SNLPINWPQK
GEIQFKNVEI KYRPNLKPSL KNISFDIKSN EKIGIVGKSG SGKSTTMLAL FRMIECSKGS
IHIDGIDISK ISLSKLRNSI GICPQEPFIF SGTIRKNIDP FGIYSDSEIW LALEKVKLKE
TISLLPMKID TIIHEQANLS FGQKQLLCLT RVLLKSPKLV FFDEHSSSID YFTAHQLNIS
VKENITNSTT LTIAHRIDTI IDSDRILVID SGELIEIFDK NNINNNINNQ NSKFKKFVQH
TSDHFKNY
