BBM_ARATH
ID BBM_ARATH Reviewed; 584 AA.
AC Q6PQQ4; Q8LSN1; Q9LF42;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=AP2-like ethylene-responsive transcription factor BBM {ECO:0000303|PubMed:12172019};
DE Short=AtBBM {ECO:0000303|PubMed:12172019};
DE AltName: Full=Protein AINTEGUMENTA-LIKE 2 {ECO:0000303|PubMed:15988559};
DE AltName: Full=Protein BABY BOOM {ECO:0000303|PubMed:12172019};
GN Name=BBM {ECO:0000303|PubMed:12172019};
GN Synonyms=AIL2 {ECO:0000303|PubMed:15988559};
GN OrderedLocusNames=At5g17430 {ECO:0000312|Araport:AT5G17430};
GN ORFNames=T10B6.90 {ECO:0000312|EMBL:CAC01738.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=cv. C24;
RX PubMed=12172019; DOI=10.1105/tpc.001941;
RA Boutilier K., Offringa R., Sharma V.K., Kieft H., Ouellet T., Zhang L.,
RA Hattori J., Liu C.-M., Van Lammeren A.A.M., Miki B.L.A., Custers J.B.M.,
RA Van Lookeren Campagne M.M.;
RT "Ectopic expression of BABY BOOM triggers a conversion from vegetative to
RT embryonic growth.";
RL Plant Cell 14:1737-1749(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pan Y., Gong W., Liu D., Fu Q., Mei W.-Q., Song W.-Q., Ma L.-G., Luo J.-C.,
RA Deng X.-W., Zhu Y.-X.;
RT "Molecular cloning, expression, phylogenetic and functional
RT characterization of the Arabidopsis AP2/EREBP transcription factor
RT family.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15988559; DOI=10.1007/s11103-005-0955-6;
RA Nole-Wilson S., Tranby T.L., Krizek B.A.;
RT "AINTEGUMENTA-like (AIL) genes are expressed in young tissues and may
RT specify meristematic or division-competent states.";
RL Plant Mol. Biol. 57:613-628(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [7]
RP FUNCTION, INTERACTION WITH HDG1; HDG2; HDG3; HDG10; ANL2; ATML1; PDF2;
RP HDG11 AND HDG12, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=25564655; DOI=10.1242/dev.117168;
RA Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL Development 142:454-464(2015).
CC -!- FUNCTION: Transcription factor that, in opposition to HDG1, promotes
CC cell proliferation and morphogenesis via transcriptionnal activation of
CC meristem and cell proliferation genes, but prevents differentiation,
CC especially during embryogenesis (PubMed:12172019, PubMed:25564655).
CC Binds to the promoter and triggers the expression of epidermally
CC expressed genes such as GSO1, GSO2, ACR4 and WER, and of HD-ZIP
CC homeobox genes including PDF2, HDG1, HDG5, HDG7, HDG8, HDG11, ANL2,
CC PDF2 and ATML1 (PubMed:25564655). {ECO:0000269|PubMed:12172019,
CC ECO:0000269|PubMed:25564655}.
CC -!- SUBUNIT: Interacts with HDG1, HDG2, HDG3, HDG10, ANL2, ATML1, PDF2,
CC HDG11 and HDG12. {ECO:0000269|PubMed:25564655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in developing seeds. Also
CC expressed in roots, seedlings, and siliques, and, at low levels, in
CC leaves. {ECO:0000269|PubMed:12172019, ECO:0000269|PubMed:15988559}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo during embryogenesis, first
CC throughoutthe embryo, but later basally localized at the heart stage
CC (PubMed:12172019, PubMed:25564655). Also present in free nuclear
CC endosperm, but disappears once endosperm cellularization begins
CC (PubMed:12172019). Observed in the stem cell niche and the provascular
CC tissue of mature roots (PubMed:25564655). {ECO:0000269|PubMed:12172019,
CC ECO:0000269|PubMed:25564655}.
CC -!- MISCELLANEOUS: Was named 'Baby boom' because overexpressing transgenic
CC plants exhibit several spontaneous somatic embryos.
CC {ECO:0000305|PubMed:12172019}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. AP2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF317907; AAM33803.1; -; Genomic_DNA.
DR EMBL; AY585684; AAS97941.1; -; mRNA.
DR EMBL; AL391142; CAC01738.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92425.1; -; Genomic_DNA.
DR PIR; T51580; T51580.
DR RefSeq; NP_197245.2; NM_121749.3.
DR AlphaFoldDB; Q6PQQ4; -.
DR SMR; Q6PQQ4; -.
DR BioGRID; 16885; 3.
DR STRING; 3702.AT5G17430.1; -.
DR iPTMnet; Q6PQQ4; -.
DR PaxDb; Q6PQQ4; -.
DR PRIDE; Q6PQQ4; -.
DR ProteomicsDB; 240644; -.
DR EnsemblPlants; AT5G17430.1; AT5G17430.1; AT5G17430.
DR GeneID; 831609; -.
DR Gramene; AT5G17430.1; AT5G17430.1; AT5G17430.
DR KEGG; ath:AT5G17430; -.
DR Araport; AT5G17430; -.
DR TAIR; locus:2178915; AT5G17430.
DR eggNOG; ENOG502QSTN; Eukaryota.
DR HOGENOM; CLU_013549_3_0_1; -.
DR InParanoid; Q6PQQ4; -.
DR OMA; DQNHHRT; -.
DR OrthoDB; 455685at2759; -.
DR PhylomeDB; Q6PQQ4; -.
DR PRO; PR:Q6PQQ4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6PQQ4; baseline and differential.
DR Genevisible; Q6PQQ4; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR CDD; cd00018; AP2; 2.
DR Gene3D; 3.30.730.10; -; 2.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 2.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 2.
DR SUPFAM; SSF54171; SSF54171; 2.
DR PROSITE; PS51032; AP2_ERF; 2.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..584
FT /note="AP2-like ethylene-responsive transcription factor
FT BBM"
FT /id="PRO_0000112525"
FT DNA_BIND 210..276
FT /note="AP2/ERF 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT DNA_BIND 312..370
FT /note="AP2/ERF 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 150..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 88..90
FT /note="NIN -> TLT (in Ref. 1; AAM33803)"
FT /evidence="ECO:0000305"
FT CONFLICT 244..246
FT /note="Missing (in Ref. 3; CAC01738)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="T -> P (in Ref. 1; AAM33803)"
FT /evidence="ECO:0000305"
FT CONFLICT 277
FT /note="L -> M (in Ref. 2; AAS97941)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="Missing (in Ref. 2; AAS97941)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 584 AA; 64545 MW; D3F4D2BF06E9BD81 CRC64;
MNSMNNWLGF SLSPHDQNHH RTDVDSSTTR TAVDVAGGYC FDLAAPSDES SAVQTSFLSP
FGVTLEAFTR DNNSHSRDWD INGGACNNIN NNEQNGPKLE NFLGRTTTIY NTNETVVDGN
GDCGGGDGGG GGSLGLSMIK TWLSNHSVAN ANHQDNGNGA RGLSLSMNSS TSDSNNYNNN
DDVVQEKTIV DVVETTPKKT IESFGQRTSI YRGVTRHRWT GRYEAHLWDN SCKREGQTRK
GRQVYLGGYD KEEKAARAYD LAALKYWGTT TTTNFPLSEY EKEVEEMKHM TRQEYVASLR
RKSSGFSRGA SIYRGVTRHH QHGRWQARIG RVAGNKDLYL GTFGTQEEAA EAYDIAAIKF
RGLSAVTNFD MNRYNVKAIL ESPSLPIGSS AKRLKDVNNP VPAMMISNNV SESANNVSGW
QNTAFQHHQG MDLSLLQQQQ ERYVGYYNGG NLSTESTRVC FKQEEEQQHF LRNSPSHMTN
VDHHSSTSDD SVTVCGNVVS YGGYQGFAIP VGTSVNYDPF TAAEIAYNAR NHYYYAQHQQ
QQQIQQSPGG DFPVAISNNH SSNMYFHGEG GGEGAPTFSV WNDT
