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BBOF1_DANRE
ID   BBOF1_DANRE             Reviewed;         520 AA.
AC   Q08C53; A8Y5S8;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Basal body-orientation factor 1 {ECO:0000250|UniProtKB:Q8ND07};
DE   AltName: Full=Coiled-coil domain-containing protein 176;
GN   Name=bbof1 {ECO:0000250|UniProtKB:Q8ND07}; Synonyms=ccdc176;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Basal body protein required in multiciliate cells to align
CC       and maintain cilia orientation in response to flow. May act by
CC       mediating a maturation step that stabilizes and aligns cilia
CC       orientation. Not required to respond to planar cell polarity (PCP) or
CC       flow-based orientation cues (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes to a polar structure adjacent to the
CC       basal body. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BBOF1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI24394.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL929282; CAP19603.1; -; Genomic_DNA.
DR   EMBL; BC124393; AAI24394.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q08C53; -.
DR   SMR; Q08C53; -.
DR   STRING; 7955.ENSDARP00000090497; -.
DR   PaxDb; Q08C53; -.
DR   ZFIN; ZDB-GENE-081105-138; si:ch211-163l21.10.
DR   eggNOG; ENOG502QRCW; Eukaryota.
DR   InParanoid; Q08C53; -.
DR   TreeFam; TF329828; -.
DR   PRO; PR:Q08C53; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR029582; Bbof1.
DR   InterPro; IPR032777; DUF4515.
DR   PANTHER; PTHR14845:SF5; PTHR14845:SF5; 1.
DR   Pfam; PF14988; DUF4515; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..520
FT                   /note="Basal body-orientation factor 1"
FT                   /id="PRO_0000281126"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..175
FT                   /evidence="ECO:0000255"
FT   COILED          245..386
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  59717 MW;  41ED9FF059976B04 CRC64;
     MPKKKGKGKG KGKGKGKGKK DGKHDSKADR ESEIEKLKSN ASLWEAKFTV TDISRLEYRE
     AARALAKANE ELENQQYRAE KDTKDIIAFL KRTDFEKTAT IAALEEELKR ERAKSAQEKD
     LLVAEYMQKI DALEEMFRQR SGDFQRMQGE LKTIKHYRKI KANLEEDLIS IREKMYVDGR
     AHQESLARTE YKFYMARIRI EKEAEQKISQ LAEQAHYEAV DQLGAASQTV ITENIRLNEG
     LDYHVKEAEQ LKRINVALTE KNSSLALFKE TNELMKKEAD SHVQSQHSEI SELTAKLSTL
     EQALGIMSRE FEQERVEMER SAGVNNTELE ELEMLLAARE KELSKVKQLA QSIIEQRREL
     ELFFHEALNH ARKEIKAQQQ HYRQEALKSY RWRMNEAHAG RLEFPRIRTF SNAPNSTNDV
     QTELEDSDKW NNLRSSNVDI SDLTWEQKER LLNLLFAKLN GIKTRKAAHP PALSASSSEK
     IQVSSDAGST VESPSMTFIT QMTMANMTSD PFVLPALKST
 
 
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