BBOF1_DANRE
ID BBOF1_DANRE Reviewed; 520 AA.
AC Q08C53; A8Y5S8;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Basal body-orientation factor 1 {ECO:0000250|UniProtKB:Q8ND07};
DE AltName: Full=Coiled-coil domain-containing protein 176;
GN Name=bbof1 {ECO:0000250|UniProtKB:Q8ND07}; Synonyms=ccdc176;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Basal body protein required in multiciliate cells to align
CC and maintain cilia orientation in response to flow. May act by
CC mediating a maturation step that stabilizes and aligns cilia
CC orientation. Not required to respond to planar cell polarity (PCP) or
CC flow-based orientation cues (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250}. Note=Localizes to a polar structure adjacent to the
CC basal body. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BBOF1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI24394.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL929282; CAP19603.1; -; Genomic_DNA.
DR EMBL; BC124393; AAI24394.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q08C53; -.
DR SMR; Q08C53; -.
DR STRING; 7955.ENSDARP00000090497; -.
DR PaxDb; Q08C53; -.
DR ZFIN; ZDB-GENE-081105-138; si:ch211-163l21.10.
DR eggNOG; ENOG502QRCW; Eukaryota.
DR InParanoid; Q08C53; -.
DR TreeFam; TF329828; -.
DR PRO; PR:Q08C53; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR InterPro; IPR029582; Bbof1.
DR InterPro; IPR032777; DUF4515.
DR PANTHER; PTHR14845:SF5; PTHR14845:SF5; 1.
DR Pfam; PF14988; DUF4515; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..520
FT /note="Basal body-orientation factor 1"
FT /id="PRO_0000281126"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..175
FT /evidence="ECO:0000255"
FT COILED 245..386
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 59717 MW; 41ED9FF059976B04 CRC64;
MPKKKGKGKG KGKGKGKGKK DGKHDSKADR ESEIEKLKSN ASLWEAKFTV TDISRLEYRE
AARALAKANE ELENQQYRAE KDTKDIIAFL KRTDFEKTAT IAALEEELKR ERAKSAQEKD
LLVAEYMQKI DALEEMFRQR SGDFQRMQGE LKTIKHYRKI KANLEEDLIS IREKMYVDGR
AHQESLARTE YKFYMARIRI EKEAEQKISQ LAEQAHYEAV DQLGAASQTV ITENIRLNEG
LDYHVKEAEQ LKRINVALTE KNSSLALFKE TNELMKKEAD SHVQSQHSEI SELTAKLSTL
EQALGIMSRE FEQERVEMER SAGVNNTELE ELEMLLAARE KELSKVKQLA QSIIEQRREL
ELFFHEALNH ARKEIKAQQQ HYRQEALKSY RWRMNEAHAG RLEFPRIRTF SNAPNSTNDV
QTELEDSDKW NNLRSSNVDI SDLTWEQKER LLNLLFAKLN GIKTRKAAHP PALSASSSEK
IQVSSDAGST VESPSMTFIT QMTMANMTSD PFVLPALKST