BBOF1_MOUSE
ID BBOF1_MOUSE Reviewed; 533 AA.
AC Q3V079; B9EKT3; Q9CUZ3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Basal body-orientation factor 1 {ECO:0000250|UniProtKB:Q8ND07};
DE AltName: Full=Coiled-coil domain-containing protein 176;
GN Name=Bbof1 {ECO:0000250|UniProtKB:Q8ND07}; Synonyms=Ccdc176;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Basal body protein required in multiciliate cells to align
CC and maintain cilia orientation in response to flow. May act by
CC mediating a maturation step that stabilizes and aligns cilia
CC orientation. Not required to respond to planar cell polarity (PCP) or
CC flow-based orientation cues (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250}. Note=Localizes to a polar structure adjacent to the
CC basal body. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BBOF1 family. {ECO:0000305}.
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DR EMBL; AK013494; BAB28880.1; -; mRNA.
DR EMBL; AK133381; BAE21625.1; -; mRNA.
DR EMBL; BC151099; AAI51100.1; -; mRNA.
DR EMBL; BC151103; AAI51104.1; -; mRNA.
DR CCDS; CCDS36492.1; -.
DR RefSeq; NP_082653.2; NM_028377.3.
DR AlphaFoldDB; Q3V079; -.
DR SMR; Q3V079; -.
DR STRING; 10090.ENSMUSP00000080512; -.
DR iPTMnet; Q3V079; -.
DR PhosphoSitePlus; Q3V079; -.
DR jPOST; Q3V079; -.
DR PaxDb; Q3V079; -.
DR PeptideAtlas; Q3V079; -.
DR PRIDE; Q3V079; -.
DR ProteomicsDB; 273464; -.
DR Antibodypedia; 156; 33 antibodies from 13 providers.
DR DNASU; 72873; -.
DR Ensembl; ENSMUST00000081828; ENSMUSP00000080512; ENSMUSG00000057265.
DR GeneID; 72873; -.
DR KEGG; mmu:72873; -.
DR UCSC; uc007ofi.2; mouse.
DR CTD; 80127; -.
DR MGI; MGI:1920123; Bbof1.
DR VEuPathDB; HostDB:ENSMUSG00000057265; -.
DR eggNOG; ENOG502QRCW; Eukaryota.
DR GeneTree; ENSGT00940000154427; -.
DR HOGENOM; CLU_032853_0_0_1; -.
DR InParanoid; Q3V079; -.
DR OMA; CMTKEFE; -.
DR OrthoDB; 792496at2759; -.
DR PhylomeDB; Q3V079; -.
DR TreeFam; TF329828; -.
DR BioGRID-ORCS; 72873; 0 hits in 40 CRISPR screens.
DR ChiTaRS; Bbof1; mouse.
DR PRO; PR:Q3V079; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3V079; protein.
DR Bgee; ENSMUSG00000057265; Expressed in seminiferous tubule of testis and 157 other tissues.
DR ExpressionAtlas; Q3V079; baseline and differential.
DR Genevisible; Q3V079; MM.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR InterPro; IPR029582; Bbof1.
DR InterPro; IPR032777; DUF4515.
DR PANTHER; PTHR14845:SF5; PTHR14845:SF5; 1.
DR Pfam; PF14988; DUF4515; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..533
FT /note="Basal body-orientation factor 1"
FT /id="PRO_0000281125"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 34..207
FT /evidence="ECO:0000255"
FT COILED 246..368
FT /evidence="ECO:0000255"
FT COMPBIAS 8..23
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 163
FT /note="I -> M (in Ref. 1; BAE21625)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 533 AA; 62499 MW; B12FCD2A93C4D6FC CRC64;
MPAKDKRKDK RKDKRKGKNK GKEPKKIIKS DEPAIERAKA NASLWEARLE VTELSRIEYR
DTSRRLAKNN EDLKKQQYNM EKDIMSVLSY LKKQDQEKDN MIEKLKQQLA KTKEKAQEEK
EKLEQKYALQ VSELEGQFHQ KAKEIGMIQT ELKTIKQFQK RKIQVEKELD DLKENLRNSE
KNYQETLRRL ESRFFEEKHR LEQEAEKRII MLAERAHHEA VVQLNTAGRN VFKENVYLHK
ALAYHLKEAE ILQQNSKKIE ENHSCLLQQK EINDLLVKEK IMQLTQQKSQ IQTLQKKVVS
LENALTYMTT EFEAEVLKLQ QKAIIENQAG LVEIDKLQQL LQMKDREMNR VKRLAKNILD
ERTEVEQFFL DALYEVKQQI LASRKHYKQI AQAAFNLKMR AACAGKTEYP RIRTFDGKEQ
STNSVNQDLL EAEKWPTTQK NVDIRDLTWE QKEKVLRLLF AKMNGFAARK YSQSSKPPVP
DHIIYGSGEM KETGDENNLL DQTFITQQAP VSDSNRMVSP DVIPQGLQDS DIA
