ID   BBP_CRYNJ               Reviewed;         546 AA.
AC   P0CO44; Q55TV5; Q5KII2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Branchpoint-bridging protein;
GN   Name=BBP; OrderedLocusNames=CND02880;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the
CC       recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract
CC       and the 3'-splice site at the 3'-end of introns (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BBP/SF1 family. {ECO:0000305}.
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DR   EMBL; AE017344; AAW42902.1; -; Genomic_DNA.
DR   RefSeq; XP_570209.1; XM_570209.1.
DR   AlphaFoldDB; P0CO44; -.
DR   SMR; P0CO44; -.
DR   STRING; 5207.AAW42902; -.
DR   PaxDb; P0CO44; -.
DR   EnsemblFungi; AAW42902; AAW42902; CND02880.
DR   GeneID; 3257032; -.
DR   KEGG; cne:CND02880; -.
DR   VEuPathDB; FungiDB:CND02880; -.
DR   eggNOG; KOG0119; Eukaryota.
DR   HOGENOM; CLU_016864_3_1_1; -.
DR   InParanoid; P0CO44; -.
DR   OMA; NVICRLC; -.
DR   OrthoDB; 887669at2759; -.
DR   Proteomes; UP000002149; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0045131; F:pre-mRNA branch point binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR045071; BBP-like.
DR   InterPro; IPR031150; BBP/SF1.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR032570; SF1-HH.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR11208; PTHR11208; 1.
DR   PANTHER; PTHR11208:SF45; PTHR11208:SF45; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF16275; SF1-HH; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00322; KH; 1.
DR   SMART; SM00343; ZnF_C2HC; 2.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
DR   PROSITE; PS50158; ZF_CCHC; 2.
PE   3: Inferred from homology;
KW   Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; RNA-binding; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..546
FT                   /note="Branchpoint-bridging protein"
FT                   /id="PRO_0000256147"
FT   DOMAIN          251..330
FT                   /note="KH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   ZN_FING         368..385
FT                   /note="CCHC-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         393..410
FT                   /note="CCHC-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          1..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   546 AA;  60795 MW;  31AAAE585C4AAFEE CRC64;
     MWRPAAKTTG TNDVPLANKR RFGLPEEGPP SNSPSYAPRP AADIQYFNGR QERERDARDD
     RERPRDDYDR RRDDYVRDDR DRRYDDYPRD GHSDRRDERS KWDEGDRREA PRGRERSRDR
     GDSNEDGPRK RRSRWGDASA KVNVPGMPVA VMGNVSQTEL DNYAIHVRLE EINRKLRTGD
     VVPPEGQRSP SPTPQYDAYG RRTNTRELRY RKKLEDERTR LIDRAVKSDP NFRPPVDFQH
     KRGSRPQDKV YIPVKEFPEI NFFGLLVGPR GNSLKKMERE SGAKISIRGK GSVKEGKGRA
     GNFPQDEEDE LHCLITADDE SKVKTCVALI NKVIETAAST PEGENDHKRN QLRELASLNG
     TLRDDENQLC QNCGEKGHRR WECPQQRVYS ANVICRICGG AGHMARDCRG RGDPSLTQNK
     QTAFDSEYTA LMAELGEGGG STPGSAPAAA IGAPGAIPPQ SRVPPWRLPE NWQTNSGGFR
     GPPNFQAQGY QQAAPGAAAY GQQAYPGYAG YQTGAVSGYG SPATGGADAY AAYYASMGQQ
     APAAAV