BBP_DICDI
ID BBP_DICDI Reviewed; 501 AA.
AC Q54BM5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Branchpoint-bridging protein;
DE AltName: Full=Splicing factor 1;
GN Name=sf1; ORFNames=DDB_G0293554;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Necessary for the splicing of pre-mRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BBP/SF1 family. {ECO:0000305}.
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DR EMBL; AAFI02000218; EAL60589.1; -; Genomic_DNA.
DR RefSeq; XP_629004.1; XM_629002.1.
DR AlphaFoldDB; Q54BM5; -.
DR SMR; Q54BM5; -.
DR STRING; 44689.DDB0233391; -.
DR PaxDb; Q54BM5; -.
DR PRIDE; Q54BM5; -.
DR EnsemblProtists; EAL60589; EAL60589; DDB_G0293554.
DR GeneID; 8629288; -.
DR KEGG; ddi:DDB_G0293554; -.
DR dictyBase; DDB_G0293554; sf1.
DR eggNOG; KOG0119; Eukaryota.
DR HOGENOM; CLU_447989_0_0_1; -.
DR InParanoid; Q54BM5; -.
DR OMA; RERPAYM; -.
DR PhylomeDB; Q54BM5; -.
DR PRO; PR:Q54BM5; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0000243; C:commitment complex; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0045131; F:pre-mRNA branch point binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; ISS:dictyBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:dictyBase.
DR GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.1370.10; -; 1.
DR InterPro; IPR045071; BBP-like.
DR InterPro; IPR031150; BBP/SF1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR032570; SF1-HH.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR11208; PTHR11208; 1.
DR PANTHER; PTHR11208:SF45; PTHR11208:SF45; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF16275; SF1-HH; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; SSF54791; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..501
FT /note="Branchpoint-bridging protein"
FT /id="PRO_0000365735"
FT DOMAIN 194..261
FT /note="KH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT ZN_FING 307..324
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 57513 MW; 3B8B89254819AA89 CRC64;
MSPNDVEQQQ LPTQNNNYND NINSPSLNDD DEDSFFREIK EISRGRPKTR DEIQISDRTR
LSRWDTPLTN DGVSPFSSIF KTLPPGLTDE QIAALILRLR VDEITKKITI GPIEFTERDR
ERSPSPPPTY DNNGKRSNTR EQRIKEKLQK ERHQLVVTAQ QINPTYKPPS DYQPPNEKKT
RKIYIPIKNH PEYNFIGLII GPRGNTQKRM EKESGAKIAI RGKGSSRDGK PTKLQFQEND
ELHVLLTADT VDQLDKAEVL VREFLIPVEE GKNEHKRQQL RELAEMNGTL RERPAYMGNR
SWTPVDIKCV QCGETSHPSS DCPLRSNESN QQYIESEYQK FIDEMSKSLG FDISISPNQN
DNSLQNINLN NNNNNSNGNN NGNNNGRNFN NDTVGDMDES PPHHTQSHFQ QNSPQFDQQQ
HQQQWNNNNN NNNNNNHNNN NNNNNNNNNN NNNNNNNNNN NNNNNNFSNY NNNNQSFYNN
NNSPYGPPNG GSPYGPPRNT Y
