RS9_RAT
ID RS9_RAT Reviewed; 194 AA.
AC P29314; Q6P9W7;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=40S ribosomal protein S9;
GN Name=Rps9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=8503895; DOI=10.1006/bbrc.1993.1596;
RA Chan Y.-L., Paz V., Olvera J., Wool I.G.;
RT "The primary structure of rat ribosomal protein S9.";
RL Biochem. Biophys. Res. Commun. 193:106-112(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Identified in a IGF2BP1-dependent mRNP granule complex
CC containing untranslated mRNAs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localized in
CC cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000305}.
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DR EMBL; X66370; CAA47013.1; -; mRNA.
DR EMBL; BC060560; AAH60560.1; -; mRNA.
DR PIR; JN0587; S21497.
DR RefSeq; NP_001300864.1; NM_001313935.1.
DR RefSeq; NP_112370.2; NM_031108.4.
DR AlphaFoldDB; P29314; -.
DR SMR; P29314; -.
DR BioGRID; 249644; 5.
DR IntAct; P29314; 8.
DR STRING; 10116.ENSRNOP00000015234; -.
DR iPTMnet; P29314; -.
DR PhosphoSitePlus; P29314; -.
DR jPOST; P29314; -.
DR PaxDb; P29314; -.
DR PRIDE; P29314; -.
DR Ensembl; ENSRNOT00000086622; ENSRNOP00000074779; ENSRNOG00000058909.
DR GeneID; 103689992; -.
DR GeneID; 81772; -.
DR KEGG; rno:103689992; -.
DR UCSC; RGD:619889; rat.
DR CTD; 103689992; -.
DR CTD; 6203; -.
DR RGD; 619889; Rps9.
DR eggNOG; KOG3301; Eukaryota.
DR GeneTree; ENSGT00550000074829; -.
DR HOGENOM; CLU_089738_0_0_1; -.
DR InParanoid; P29314; -.
DR OMA; ARQFITH; -.
DR OrthoDB; 1310788at2759; -.
DR PhylomeDB; P29314; -.
DR TreeFam; TF300795; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P29314; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000058909; Expressed in thymus and 19 other tissues.
DR ExpressionAtlas; P29314; baseline and differential.
DR Genevisible; P29314; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0005730; C:nucleolus; ISO:RGD.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0015935; C:small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:1990932; F:5.8S rRNA binding; IDA:RGD.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0045182; F:translation regulator activity; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0045903; P:positive regulation of translational fidelity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; ISO:RGD.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR005710; Ribosomal_S4/S9_euk/arc.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR018079; Ribosomal_S4_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR TIGRFAMs; TIGR01018; uS4_arch; 1.
DR PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding; Ubl conjugation.
FT CHAIN 1..194
FT /note="40S ribosomal protein S9"
FT /id="PRO_0000132692"
FT DOMAIN 108..182
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT REGION 162..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 66
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZWN5"
FT MOD_RES 116
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZWN5"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P46781"
FT MOD_RES 155
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P46781"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P46781"
FT CROSSLNK 93
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P46781"
FT CROSSLNK 139
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P46781"
FT CONFLICT 138
FT /note="R -> L (in Ref. 1; CAA47013)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="R -> L (in Ref. 1; CAA47013)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 194 AA; 22591 MW; E9CE3CBD59524F81 CRC64;
MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL
LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA
KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK
GQGGAGAGDD EEED
