ABCC9_DICDI
ID ABCC9_DICDI Reviewed; 1345 AA.
AC Q54NL1; Q8T6H0;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=ABC transporter C family member 9;
DE AltName: Full=ABC transporter ABCC.9;
GN Name=abcC9; ORFNames=DDB_G0285165;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AF474341; AAL85712.1; -; Genomic_DNA.
DR EMBL; AAFI02000075; EAL64839.1; -; Genomic_DNA.
DR RefSeq; XP_638351.1; XM_633259.1.
DR AlphaFoldDB; Q54NL1; -.
DR SMR; Q54NL1; -.
DR STRING; 44689.DDB0216237; -.
DR PaxDb; Q54NL1; -.
DR PRIDE; Q54NL1; -.
DR EnsemblProtists; EAL64839; EAL64839; DDB_G0285165.
DR GeneID; 8624976; -.
DR KEGG; ddi:DDB_G0285165; -.
DR dictyBase; DDB_G0285165; abcC9.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_3_1; -.
DR InParanoid; Q54NL1; -.
DR OMA; WISIRLE; -.
DR PhylomeDB; Q54NL1; -.
DR Reactome; R-DDI-159418; Recycling of bile acids and salts.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-9749641; Aspirin ADME.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR PRO; PR:Q54NL1; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031153; P:slug development involved in sorocarp development; HMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1345
FT /note="ABC transporter C family member 9"
FT /id="PRO_0000363854"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 817..837
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 906..926
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1008..1028
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 135..419
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 481..703
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 775..1060
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1103..1338
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 460..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 21..55
FT /evidence="ECO:0000255"
FT COILED 709..739
FT /evidence="ECO:0000255"
FT COMPBIAS 463..484
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1137..1144
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 273
FT /note="S -> P (in Ref. 1; AAL85712)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1345 AA; 154402 MW; 54E539F9382C372E CRC64;
MIRNKIKNKK SKSDYYSEIS LEEEEDKEEE IKDKKVLSKE EIKENENKNE KIKQTQCPED
NASLFSKITF GWITKLIVKA YIKKSLDIKD IFDVPNYLKS NYTSKFLTTE KQTFKRNTKY
SLILNIYINF ILLKNKKLIL IQFLRVLFTL LSPLILKLFI EFTQRIDSEK SIIEGIIYCG
LLFFSSFCSS LVDEYLVWFG MITSSQVKSC LTCLIFEKSL KLSNSAKVKY NAAKITNLIS
IDVDNFSNFF WSNSVEIFFQ PFQLIFLLIL LISEVGWSGF VGTAVILISF PINSYFGKKT
SDYYEKLLKY TDKRVSTTSE FINGIRFIKM YAWESLFLKK IEKQRKQELK ILLERGLFWL
GQIIIINTNS TFVFVATMVT YSLSGNKMKL ETAFTAMNIL DSIRILLIVM PYCYYSIMEL
IPSNKRIEKF LSTLEIQQNL QTTKNSNTIS INNGTFKWKD ENFEETDDDD DHDDDDDEGE
KEIEGKEEKE EINNFIFENI NFKAPIGKLT MICSPVGSGK TSLINALIGE IEKVNGEING
VPENISFTSQ QPFLLSTSLR ENILFGKELD IEYYKQVLDA CCLVSDLTQL SALDLTEIGE
GGINLSGGQK QRVSLARALY SNSDFILMDE PLSAVDPEVA NHLFEKCIQG MMKNKTRILV
THQIQFIPYA DHIVIIKDGK IIQGTYKELK DENGIDFESI IKTKNSNLNL NKTIKDEEEK
EDKEGEEKEE DKKEMILKLI KINYSDELKE KAKLLVEEDR NEGEVSFKTY KEYFYYGSSN
LFLFITLLVF LIGLIVNRLS DFWLTIWTEQ SFKEKSQTFY IICFVSIFIV SLILIFIRYS
LVAKIGFKSS KKLHDLLINS ISKSPIQFFD SNPSGRILNR FSNDISDIDT SMIDMFSDTL
EYIFAIVVGI FSIIYINPMT IVPFLILSMF YYQIFNIYRV SVRELNRCKS ISQSPIISFL
SECCNGLSTI RAFKQQSRFI GIMNDNIDKN LKCEFASFAV EMWISIRLEL LSSIIVFIVS
LFSLFNGYSN SALSILSVST ARSITSYLKS ACRQMVDLER KMNSFERVNN YIKLPSEGSG
SGVKSMEFIS EKDLLNWPEK GNIQFNNVQV NYNSNSVPSL KDITFSVESN EKIGIVGRTG
AGKSTIANCL FRLVECSKGS ILIDGIDIKT IDLNKLRGSL GIVPQEPWLF SGTIRSNIDP
LNQYDDEMIW NYLEMVKLKK LIIEMPLKLN SKIHENGNTT LSYGQKQLLC LCRCLIKNPK
LIIMDEATSS VDFQTAETIK SVINENLVNN TILTIAHRLD IIIDSDKIAV IDNSKLIEFE
NPKNLINSNS KFRKIVNFQT KIQTN
