BBS10_MOUSE
ID BBS10_MOUSE Reviewed; 713 AA.
AC Q9DBI2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Bardet-Biedl syndrome 10 protein homolog;
GN Name=Bbs10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Probable molecular chaperone that assists the folding of
CC proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a
CC complex involved in ciliogenesis regulating transports vesicles to the
CC cilia. Involved in adipogenic differentiation.
CC {ECO:0000250|UniProtKB:Q8TAM1}.
CC -!- SUBUNIT: Component of a complex composed at least of MKKS, BBS10,
CC BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.
CC {ECO:0000250|UniProtKB:Q8TAM1}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q8TAM1}. Note=Located within the basal body of
CC the primary cilium of differentiating preadipocytes.
CC {ECO:0000250|UniProtKB:Q8TAM1}.
CC -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB23682.1; Type=Miscellaneous discrepancy; Note=Intron retention. Several introns.; Evidence={ECO:0000305};
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DR EMBL; AK004937; BAB23682.1; ALT_SEQ; mRNA.
DR CCDS; CCDS48689.1; -.
DR RefSeq; NP_082190.1; NM_027914.1.
DR AlphaFoldDB; Q9DBI2; -.
DR DIP; DIP-60356N; -.
DR IntAct; Q9DBI2; 4.
DR STRING; 10090.ENSMUSP00000049387; -.
DR iPTMnet; Q9DBI2; -.
DR PhosphoSitePlus; Q9DBI2; -.
DR PaxDb; Q9DBI2; -.
DR PeptideAtlas; Q9DBI2; -.
DR PRIDE; Q9DBI2; -.
DR ProteomicsDB; 273731; -.
DR Antibodypedia; 29650; 171 antibodies from 27 providers.
DR Ensembl; ENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759.
DR GeneID; 71769; -.
DR KEGG; mmu:71769; -.
DR UCSC; uc011xnf.1; mouse.
DR CTD; 79738; -.
DR MGI; MGI:1919019; Bbs10.
DR VEuPathDB; HostDB:ENSMUSG00000035759; -.
DR eggNOG; KOG0357; Eukaryota.
DR eggNOG; KOG0360; Eukaryota.
DR GeneTree; ENSGT00390000002417; -.
DR HOGENOM; CLU_028678_0_0_1; -.
DR InParanoid; Q9DBI2; -.
DR OMA; AKTFIIF; -.
DR OrthoDB; 1411586at2759; -.
DR PhylomeDB; Q9DBI2; -.
DR TreeFam; TF335867; -.
DR Reactome; R-MMU-5620922; BBSome-mediated cargo-targeting to cilium.
DR BioGRID-ORCS; 71769; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Bbs10; mouse.
DR PRO; PR:Q9DBI2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9DBI2; protein.
DR Bgee; ENSMUSG00000035759; Expressed in spermatocyte and 164 other tissues.
DR Genevisible; Q9DBI2; MM.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0051131; P:chaperone-mediated protein complex assembly; ISO:MGI.
DR GO; GO:1905515; P:non-motile cilium assembly; ISO:MGI.
DR GO; GO:0045494; P:photoreceptor cell maintenance; ISO:MGI.
DR GO; GO:0043254; P:regulation of protein-containing complex assembly; ISO:MGI.
DR Gene3D; 1.10.560.10; -; 2.
DR Gene3D; 3.30.260.10; -; 1.
DR Gene3D; 3.50.7.10; -; 1.
DR InterPro; IPR042619; BBS10.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR027413; GROEL-like_equatorial_sf.
DR InterPro; IPR027410; TCP-1-like_intermed_sf.
DR PANTHER; PTHR14667; PTHR14667; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR SUPFAM; SSF48592; SSF48592; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell projection; Chaperone; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..713
FT /note="Bardet-Biedl syndrome 10 protein homolog"
FT /id="PRO_0000235273"
SQ SEQUENCE 713 AA; 78924 MW; AEEBC611994FDB84 CRC64;
MASQGSVTAA LRVAEVLESI ANRCVGPEGG QVLCTKPTGE VLLSRDGGCL LEALHLEHPL
ARMIVACVSS HLKKTGDGAK TFIIFLCHLL RGLHAIGEKG KDSFTSENIQ SHERHWKNCC
QWKSISQALQ TFQTQTLGCI VDRSLSRHYL SVFSSSTEGR KLCRHSLELL LEAYFCGRVG
RNNHRFISQL MCDYVFKCMA CESGVEVFEL LDHCFAELNV GVTGLPVSDS RIIDGLVLPR
DFSMYCPADG DIRMVIVTEI LQPQFSSAGS EFVLNSETQF QASQCWITDR TKTVMNHLRG
QNVKLLLTSV KQPDLVIYCA RLNSISVVEC LSAEEVSLVQ RITGLSPCVL PEVASQCEIS
DSTLVKFCKP LILRSKRYVH LGLISTCAFI PHSMVLCGPV LGLVEQHERA FHGAFKMLRQ
LFTDLDLNYI IQTKQQCNPS PLAYDNSRER NHSPETDKYQ DIVAKSKNKL ETQTHLEVYS
GLGASDTELR AGKPWSAHKK TPIAPSQTDE MLKCLPPERS GIIDNCDLSI ENHSTGNPTA
EDTGTEISFE HLQVSDNAGK GYTLPVMRKS LDTCTCQGYC SSTVPAGCVL PVGGSFEILM
SYYLLSYAKQ CRQSDETVIS MLIADALLGI PKILYKPKKG KDSFPHIYMR SLHALQASQP
MVSGQSGFES VAGKYQLLTS VLQCLMKILT IDLIINIKRQ PQKTADQESE DEF
