ID   BBS12_PONAB             Reviewed;         710 AA.
AC   Q5RC62; Q5R4T6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Bardet-Biedl syndrome 12 protein homolog;
GN   Name=BBS12;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a
CC       molecular chaperone complex that assists the folding of proteins upon
CC       ATP hydrolysis. As part of the TRiC complex may play a role in the
CC       assembly of BBSome, a complex involved in ciliogenesis regulating
CC       transports vesicles to the cilia. Involved in adipogenic
CC       differentiation. {ECO:0000250|UniProtKB:Q6ZW61}.
CC   -!- SUBUNIT: Component of the chaperonin-containing T-complex (TRiC), a
CC       heterooligomeric complex of about 850 to 900 kDa that forms two stacked
CC       rings, 12 to 16 nm in diameter. Interacts with MKKS.
CC       {ECO:0000250|UniProtKB:Q6ZW61}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6ZW61}. Note=Located within the basal body of
CC       the primary cilium of differentiating preadipocytes.
CC       {ECO:0000250|UniProtKB:Q6ZW61}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. BBS12 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR858418; CAH90648.1; -; mRNA.
DR   EMBL; CR861156; CAH93230.1; -; mRNA.
DR   AlphaFoldDB; Q5RC62; -.
DR   STRING; 9601.ENSPPYP00000016807; -.
DR   eggNOG; ENOG502QUYD; Eukaryota.
DR   InParanoid; Q5RC62; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IEA:InterPro.
DR   Gene3D; 1.10.560.10; -; 2.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR042984; BBS12.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   PANTHER; PTHR46883; PTHR46883; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Reference proteome.
FT   CHAIN           1..710
FT                   /note="Bardet-Biedl syndrome 12 protein homolog"
FT                   /id="PRO_0000301983"
FT   CONFLICT        260
FT                   /note="H -> L (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        267
FT                   /note="D -> G (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        288
FT                   /note="E -> A (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        343
FT                   /note="N -> I (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        352
FT                   /note="Q -> R (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        386
FT                   /note="Q -> E (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        462
FT                   /note="E -> G (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        467
FT                   /note="D -> N (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        470
FT                   /note="C -> Y (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        486
FT                   /note="S -> N (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        514
FT                   /note="I -> T (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        551..552
FT                   /note="HI -> QV (in Ref. 1; CAH93230)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   710 AA;  79045 MW;  1272DA87145FF787 CRC64;
     MVMACRVVNK RRHMGLQQLS SFAETGRTFL GPLKSSKFII DEECHESVLI SSTVRLLESL
     DLTSAVGQLL NEAVQAQNNT YRTGISTLLF LVGAWSSAVE ECLHLGVPIS IIVSVMSEGL
     NFCSEEVVSL HVPVHNIFDC MDSTKTFSQL ETFSVSLCPF LQVPSDTDLI EELHGLKDVA
     SQTLTISNLS GRPLKSYELF KPQTKVEADN NTSRTLKNSL LADTCCRQSI LIHSRHFNRT
     DNTEGVSKPD GFQEHVTATH KTYRCNDLVE LAVGLSHGDH SSMKLVEEAV QLQYQNACVQ
     QGNCTKPFMF DISRIFTCCL PGLPETSSCV CPGYITVVSV SNNPVIKELQ NQPVRIVLIE
     GDLTENYRHL GFNKSANIKT VLDSMQLQED SSEELWANHV LQVLIQFKVN LVLVQGNVSE
     RLIEKCINSK RLVIGSVNGS VMQAFAEAAG AVQVAYITQV NEDCVGDGVC VTFWRSSPLD
     VVDRNSRIAI LLKTEGINLV TAVLTNPVTA QMQIKEDRFW TCAYRLYYAL KEEKVFLGGG
     AVEFLCLSCL HILAEQSLKK ENHACSGWLH NTSSWLASSL AIYRPTVLKF LANGWQKYLS
     TLLYNTANYS SEFEASTYIQ HHLQNATDSG SPSSYILNEY SKLNSRIFNS DISNKLEQIP
     RVYDVVTPKI EAWRRALDLV LLALQTDSEI ITGHGHTQRN SQELTGFLFL