ID   BBS12_XENLA             Reviewed;         673 AA.
AC   A5PKN5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Bardet-Biedl syndrome 12 protein homolog;
GN   Name=bbs12;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a
CC       molecular chaperone complex that assists the folding of proteins upon
CC       ATP hydrolysis. {ECO:0000250|UniProtKB:Q6ZW61}.
CC   -!- SUBUNIT: Component of the chaperonin-containing T-complex (TRiC), a
CC       heterooligomeric complex of about 850 to 900 kDa that forms two stacked
CC       rings, 12 to 16 nm in diameter. {ECO:0000250|UniProtKB:Q6ZW61}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6ZW61}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. BBS12 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC142555; AAI42556.1; -; mRNA.
DR   RefSeq; NP_001093348.1; NM_001099878.1.
DR   AlphaFoldDB; A5PKN5; -.
DR   GeneID; 100101288; -.
DR   KEGG; xla:100101288; -.
DR   CTD; 100101288; -.
DR   Xenbase; XB-GENE-5962528; bbs12.L.
DR   OrthoDB; 429087at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 100101288; Expressed in testis and 14 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IEA:InterPro.
DR   Gene3D; 1.10.560.10; -; 2.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR042984; BBS12.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   PANTHER; PTHR46883; PTHR46883; 2.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Reference proteome.
FT   CHAIN           1..673
FT                   /note="Bardet-Biedl syndrome 12 protein homolog"
FT                   /id="PRO_0000301984"
SQ   SEQUENCE   673 AA;  74882 MW;  B93822AAA2A1AA45 CRC64;
     MAIRGHKGLQ QLLSMATSVN SFLGPMKSYK FIFDQITHES ILTSSSFRLL ENLDLTSAIG
     QLLNETIQAH HKSYKTGTTT LFFMVGAWSS AVQECLHLGI PVSLIVSVML DGLNSCIGHV
     HSLQVSLVSQ VTSDCTNIKT NGINHSNYSA SGDQGNCSSE LENNPLPRVS NMRTASEFPV
     AFHKKPLPLC TGTNLYKTQR RRLFHSRHLA EDLSFFQDVP ERPQTTTLNN ETLDGLAKGL
     AHGYQPVMNL VKNAVCLHCA EIKENSLDKS SFNISRLETC SLPGLSEEHT TVSFGYTTLV
     PTESAAVITH LNGKPLRILL VDGELTESHR HLGFDNPDNV KMVFEHAGNE KHNLEDSWIS
     RAYEKIIQAN INLILVRGDV CPFLLKQCIH RNILIVTQVK QNILQAFSEC TGAEPVTYLT
     QINCCSVGNE AFVTLCTRAN SIIEVSQKIV ISITAKKLNL ITATLSSRIP STMQSIEDQF
     LTCAYRLHHA LQEGNVFYGG GAIELLCIHH LQKLVQESSS SFYAYDNAQF HCLSSWMTES
     ATFYRAAIIG CLAKGWYKYI SVLLCNMGGF LSELDAVTFI ENELQNISHH SSPIDYVRDQ
     YSKKDLFNDE MGISISHHSL PVYDNVTPKL EAWRRALHLV LTVLQTDAEV ITNSATQNQI
     LMSETSNGEY LFL