ID   RSBV_STAAC              Reviewed;         108 AA.
AC   P60071; O05343; P95842; Q5HED5;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Anti-sigma-B factor antagonist;
DE   AltName: Full=Anti-anti-sigma-B factor;
GN   Name=rsbV; OrderedLocusNames=SACOL2056;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8830703; DOI=10.1128/jb.178.20.6036-6042.1996;
RA   Wu S.-W., de Lencastre H., Tomasz A.;
RT   "Sigma-B, a putative operon encoding alternate sigma factor of
RT   Staphylococcus aureus RNA polymerase: molecular cloning and DNA
RT   sequencing.";
RL   J. Bacteriol. 178:6036-6042(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Positive regulator of sigma-B activity. Non-phosphorylated
CC       RsbV binds to RsbW, preventing its association with sigma-B. When
CC       phosphorylated, releases RsbW, which is then free to complex with and
CC       inactivate sigma-B (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated by RsbW on a serine residue. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
CC       {ECO:0000305}.
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DR   EMBL; Y09929; CAA71066.1; -; Genomic_DNA.
DR   EMBL; CP000046; AAW37018.1; -; Genomic_DNA.
DR   RefSeq; WP_001052491.1; NC_002951.2.
DR   AlphaFoldDB; P60071; -.
DR   SMR; P60071; -.
DR   EnsemblBacteria; AAW37018; AAW37018; SACOL2056.
DR   GeneID; 66840274; -.
DR   KEGG; sac:SACOL2056; -.
DR   HOGENOM; CLU_115403_9_3_9; -.
DR   OMA; MNLAINI; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR003658; Anti-sigma_ant.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   Pfam; PF01740; STAS; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00377; ant_ant_sig; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein.
FT   CHAIN           1..108
FT                   /note="Anti-sigma-B factor antagonist"
FT                   /id="PRO_0000194188"
FT   DOMAIN          3..108
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT   MOD_RES         57
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        50
FT                   /note="E -> A (in Ref. 1; CAA71066)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   108 AA;  12205 MW;  461FC096E18D9AEE CRC64;
     MNLNIETTTQ DKFYEVKVGG ELDVYTVPEL EEVLTPMRQD GTRDIYVNLE NVSYMDSTGL
     GLFVGTLKAL NQNDKELYIL GVSDRIGRLF EITGLKDLMH VNEGTEVE