BBS4_DROME
ID BBS4_DROME Reviewed; 486 AA.
AC A1Z8E9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Bardet-Biedl syndrome 4 protein homolog;
GN Name=BBS4; ORFNames=CG13232;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: May be required for microtubule anchoring at the centrosome.
CC Required for ciliogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BBS4 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58718.1; -; Genomic_DNA.
DR RefSeq; NP_610636.1; NM_136792.2.
DR AlphaFoldDB; A1Z8E9; -.
DR SMR; A1Z8E9; -.
DR STRING; 7227.FBpp0087297; -.
DR PaxDb; A1Z8E9; -.
DR EnsemblMetazoa; FBtr0088202; FBpp0087297; FBgn0033578.
DR GeneID; 36167; -.
DR KEGG; dme:Dmel_CG13232; -.
DR CTD; 585; -.
DR FlyBase; FBgn0033578; BBS4.
DR VEuPathDB; VectorBase:FBgn0033578; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00940000173860; -.
DR HOGENOM; CLU_033477_0_1_1; -.
DR InParanoid; A1Z8E9; -.
DR OMA; WNNIGAC; -.
DR OrthoDB; 609083at2759; -.
DR PhylomeDB; A1Z8E9; -.
DR Reactome; R-DME-5620922; BBSome-mediated cargo-targeting to cilium.
DR BioGRID-ORCS; 36167; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36167; -.
DR PRO; PR:A1Z8E9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033578; Expressed in antenna and 3 other tissues.
DR ExpressionAtlas; A1Z8E9; baseline and differential.
DR Genevisible; A1Z8E9; DM.
DR GO; GO:0034464; C:BBSome; ISS:FlyBase.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; ISS:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; ISS:UniProtKB.
DR GO; GO:0034452; F:dynactin binding; ISS:FlyBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IEP:FlyBase.
DR GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR028786; BBS4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44186; PTHR44186; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Membrane;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..486
FT /note="Bardet-Biedl syndrome 4 protein homolog"
FT /id="PRO_0000284045"
FT REPEAT 33..66
FT /note="TPR 1"
FT REPEAT 67..100
FT /note="TPR 2"
FT REPEAT 101..134
FT /note="TPR 3"
FT REPEAT 143..179
FT /note="TPR 4"
FT REPEAT 180..213
FT /note="TPR 5"
FT REPEAT 215..247
FT /note="TPR 6"
FT REPEAT 249..282
FT /note="TPR 7"
FT REPEAT 283..316
FT /note="TPR 8"
FT REPEAT 318..350
FT /note="TPR 9"
FT REPEAT 352..384
FT /note="TPR 10"
SQ SEQUENCE 486 AA; 55632 MW; A05176607D595430 CRC64;
MYEPGTEQIN CNGRLIELPT LEVVRPAPKM PSDANIDWLL HIYFTRREFT RCRRLIEREL
NRHLNPEYLY FVQGLIDREE GNHIEALRHL QKSAELNPRN IETYKEIGRT LYIMGRFSQA
LGVFREAEQR SSRQDHEIYH YLGELLYRAA TTQSQKDVAS QQQDEARTYF ELAVQSGRKL
ESYVRLAELY RKDKQYQKAI EILENCLHLT PENSEVLIEI SVLYLKINET QKAHDRLAEV
VSIERKCSPK GLLAFGAILQ SRNDIDGALS KYSQIANAEP EIAELWNNIG LCFFKKQKFI
VAISSLRKSV WLSPLNYNAL YNLSLIYIAS EQYASAFHTL AAAINLRKDN AECYMLLGLC
LRKLDDMENA FVALERASSM ATGQQGAGRN PLVVLNFALF CYETGRLALS TEQYNRFMSQ
AQDLLLPTEY KFQATKLKSL LRISNQGNGI LLDSADMGES DLGHNRATEL LPDELPLEVN
AVVSQN
