ID   RSBW_MYCTO              Reviewed;         168 AA.
AC   P9WGX6; Q798J8; Q7D5S1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 2.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Anti-sigma-F factor RsbW;
DE   AltName: Full=Anti-sigma-F factor UsfX;
DE   AltName: Full=Regulator of SigF;
DE   AltName: Full=Sigma-F anti-sigma factor RsbW;
GN   Name=rsbW; Synonyms=usfX; OrderedLocusNames=MT3386;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: A cognate anti-sigma factor for alternative sigma factor
CC       SigF. Alternative sigma factors are held in an inactive form by an
CC       anti-sigma factor. Binds ATP and GTP, may hydrolyze both (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK47729.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK47729.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P9WGX6; -.
DR   SMR; P9WGX6; -.
DR   EnsemblBacteria; AAK47729; AAK47729; MT3386.
DR   KEGG; mtc:MT3386; -.
DR   HOGENOM; CLU_116681_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..168
FT                   /note="Anti-sigma-F factor RsbW"
FT                   /id="PRO_0000428285"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         124..128
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   168 AA;  17928 MW;  D1E729A26DFD765E CRC64;
     MTDQLEDQTQ GGSTVDRSLP GGCMADSDLP TKGRQRGVRA VELNVAARLE NLALLRTLVG
     AIGTFEDLDF DAVADLRLAV DEVCTRLIRS ALPDATLRLV VDPRKDEVVV EASAACDTHD
     VVAPGSFSWH VLTALADDVQ TFHDGRQPDV AGSVFGITLT ARRAASSR