ID   BBS4_XENTR              Reviewed;         516 AA.
AC   Q28G25;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Bardet-Biedl syndrome 4 protein homolog;
GN   Name=bbs4; ORFNames=TGas038l03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for the dynein-mediated transport of
CC       pericentriolar proteins to the centrosome. Required for microtubule
CC       anchoring at the centrosome but not for microtubule nucleation.
CC       Required for ciliogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BBS4 family. {ECO:0000305}.
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DR   EMBL; CR761609; CAJ83807.1; -; mRNA.
DR   RefSeq; NP_001016280.1; NM_001016280.2.
DR   AlphaFoldDB; Q28G25; -.
DR   SMR; Q28G25; -.
DR   STRING; 8364.ENSXETP00000058635; -.
DR   PaxDb; Q28G25; -.
DR   GeneID; 549034; -.
DR   KEGG; xtr:549034; -.
DR   CTD; 585; -.
DR   Xenbase; XB-GENE-952107; bbs4.
DR   eggNOG; KOG1124; Eukaryota.
DR   HOGENOM; CLU_033477_0_0_1; -.
DR   InParanoid; Q28G25; -.
DR   OrthoDB; 609083at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0034451; C:centriolar satellite; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000242; C:pericentriolar material; ISS:UniProtKB.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR028786; BBS4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44186; PTHR44186; 1.
DR   Pfam; PF13181; TPR_8; 4.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 8.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..516
FT                   /note="Bardet-Biedl syndrome 4 protein homolog"
FT                   /id="PRO_0000284043"
FT   REPEAT          64..97
FT                   /note="TPR 1"
FT   REPEAT          98..131
FT                   /note="TPR 2"
FT   REPEAT          133..165
FT                   /note="TPR 3"
FT   REPEAT          166..198
FT                   /note="TPR 4"
FT   REPEAT          200..232
FT                   /note="TPR 5"
FT   REPEAT          234..266
FT                   /note="TPR 6"
FT   REPEAT          267..300
FT                   /note="TPR 7"
FT   REPEAT          302..334
FT                   /note="TPR 8"
FT   REPEAT          336..368
FT                   /note="TPR 9"
FT   REPEAT          370..402
FT                   /note="TPR 10"
FT   REGION          431..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   516 AA;  56991 MW;  ADDE5DDBA26493E5 CRC64;
     MAEEQQEVVP QESGLRKSRV QKVPELPILE RRNWLIHLHY VRKDYESCKA VIKEQLQATQ
     GVCEYAVYVQ ALILRLEGKI QESLELFQTC AVLNPTSSDN LKQVARSLFL LGKHKAAVEV
     YNEAARLNQK DWEICHNLGV CYLFLKDLSK SKEQLTLALQ LHRQDLSAIT LGKIQLQEGD
     IDGAIQTFTQ ALQLSPENTE LLTTLGLLYL QNGLFQKAFE YLGNALTYDP SNYKGILAAG
     CMMQSHGDYD VALSKYRVAA SSVPESSPLW NNIGMCFYGK KKYVAAISCL KRALYLSPFD
     WRVLYNLGLV HLSMQQYASA FHFLSAAISL HHGNAGLYML LAVALTYLDD IENAKSSYQQ
     AASLDQTDPL VNLNFAVLLY NQGDKKGALG QYQELERKVS ALRETSTEFD PEMVDMAQKL
     GAALQVGESL VWTRQTKDPK GKQRGAGKGP GAEQAPLGSN QALGRAMSSA AGYSKASGLS
     SGITISTVSK HPSLPLEPED PSLTSSTAPD YRRGHS