ID   BBS5_DANRE              Reviewed;         342 AA.
AC   Q7ZWB7;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog;
GN   Name=bbs5; ORFNames=zgc:56578;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000305}.
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DR   EMBL; BC049492; AAH49492.1; -; mRNA.
DR   RefSeq; NP_956593.1; NM_200299.1.
DR   AlphaFoldDB; Q7ZWB7; -.
DR   SMR; Q7ZWB7; -.
DR   BioGRID; 89422; 1.
DR   STRING; 7955.ENSDARP00000058254; -.
DR   PaxDb; Q7ZWB7; -.
DR   Ensembl; ENSDART00000058255; ENSDARP00000058254; ENSDARG00000039827.
DR   GeneID; 393269; -.
DR   KEGG; dre:393269; -.
DR   CTD; 129880; -.
DR   ZFIN; ZDB-GENE-040426-1083; bbs5.
DR   eggNOG; ENOG502QR2Z; Eukaryota.
DR   GeneTree; ENSGT00390000002753; -.
DR   HOGENOM; CLU_052113_0_0_1; -.
DR   InParanoid; Q7ZWB7; -.
DR   OMA; PNFGIQY; -.
DR   OrthoDB; 1257336at2759; -.
DR   PhylomeDB; Q7ZWB7; -.
DR   TreeFam; TF106129; -.
DR   Reactome; R-DRE-5620922; BBSome-mediated cargo-targeting to cilium.
DR   PRO; PR:Q7ZWB7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000039827; Expressed in retina and 31 other tissues.
DR   GO; GO:0034464; C:BBSome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR   GO; GO:0043010; P:camera-type eye development; IMP:ZFIN.
DR   GO; GO:0062139; P:camera-type eye photoreceptor cell development; IMP:ZFIN.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; IMP:ZFIN.
DR   GO; GO:0001947; P:heart looping; IMP:BHF-UCL.
DR   GO; GO:0046907; P:intracellular transport; IMP:ZFIN.
DR   GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR   GO; GO:0032402; P:melanosome transport; IMP:BHF-UCL.
DR   GO; GO:0051877; P:pigment granule aggregation in cell center; IMP:ZFIN.
DR   GO; GO:0072116; P:pronephros formation; IMP:ZFIN.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; DM16_repeat.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351; PTHR21351; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome.
FT   CHAIN           1..342
FT                   /note="Bardet-Biedl syndrome 5 protein homolog"
FT                   /id="PRO_0000223257"
SQ   SEQUENCE   342 AA;  38915 MW;  AB9A3B0DAF6541EC CRC64;
     MASVLDALWE DRDVRFDITA QQMKTRPGEA LIDCLDSIED TKGNNGDRGR LLVTNLRIIW
     HSLALPRVNL SVGYNCIINI TTRTANSKLR GQTEALYILT KSNNTRFEFI FTNVVPGSPR
     LFTSVIAVHR AYETSKMYRD LKLRGALIQN KQLRLLPQEQ VYDKINGVWN LSSDQGNLGT
     FFITNVRIVW HANMNESFNV SIPYLQIRSI RIRDSKFGLA LVIESSQQTG GYVLGFKIDP
     MDKLQDAVKE INSLHKVYSA NPIFGVEYEM EEKPQPLEEL TVEQPPDDVE IEPDEHTDAF
     TAYFADGNKQ HDREPVFSEE LGLAIEKLKD GFTLQGLWEV MG