ID   RSCA1_RABIT             Reviewed;         590 AA.
AC   O02665;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Regulatory solute carrier protein family 1 member 1;
DE   AltName: Full=Transporter regulator RS1;
DE            Short=rRS1;
GN   Name=RSC1A1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=10076042; DOI=10.1016/s0005-2736(98)00250-8;
RA   Reinhardt J., Veyhl M., Wagner K., Gambaryan S., Dekel C., Akhoundova A.,
RA   Korn T., Koepsell H.;
RT   "Cloning and characterization of the transport modifier RS1 from rabbit
RT   which was previously assumed to be specific for Na+-D-glucose
RT   cotransport.";
RL   Biochim. Biophys. Acta 1417:131-143(1999).
CC   -!- FUNCTION: Mediates transcriptional and post-transcriptional regulation
CC       of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of
CC       SLC5A1. Also involved in transcriptional regulation of SLC22A2.
CC       Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2
CC       by inhibiting the release of vesicles from the trans-Golgi network (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:10076042}.
CC   -!- SUBUNIT: Interacts with YRDC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}.
CC       Note=Localizes at the inner side of the plasma membrane. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in renal outer medulla, renal
CC       inner medulla, duodenum, ileum and jejunum. Moderately expressed in
CC       renal outer cortex, renal papilla, brain and liver.
CC       {ECO:0000269|PubMed:10076042}.
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DR   EMBL; X82876; CAA58057.1; -; mRNA.
DR   RefSeq; NP_001076243.1; NM_001082774.1.
DR   AlphaFoldDB; O02665; -.
DR   SMR; O02665; -.
DR   STRING; 9986.ENSOCUP00000014863; -.
DR   PRIDE; O02665; -.
DR   GeneID; 100009562; -.
DR   KEGG; ocu:100009562; -.
DR   CTD; 6248; -.
DR   eggNOG; KOG0012; Eukaryota.
DR   InParanoid; O02665; -.
DR   OrthoDB; 817208at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045920; P:negative regulation of exocytosis; IEA:InterPro.
DR   GO; GO:0010829; P:negative regulation of glucose transmembrane transport; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR039222; RSC1A1.
DR   InterPro; IPR015940; UBA.
DR   PANTHER; PTHR15397; PTHR15397; 1.
DR   SMART; SM00165; UBA; 1.
DR   PROSITE; PS50030; UBA; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Golgi apparatus; Membrane; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..590
FT                   /note="Regulatory solute carrier protein family 1 member 1"
FT                   /id="PRO_0000324153"
FT   DOMAIN          544..584
FT                   /note="UBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..206
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   590 AA;  62111 MW;  7EBFCC86013770DB CRC64;
     MSSSPPLDGS DHPAHSSGQS PEAGNPTSLA RSVSASVCPV KPDNPDSTEP EAVTALEASD
     GFQINSKQTD RLPLQGHSPC AAAAAPSSAM PLRHSSEAAG VADSLEASAE RRTQGLRFHL
     HTRQEVNLSI TTTRMHEPQM FAGEEGWHPE NQNPSQVNDL QQHQEPENAR HEAGPRDAPS
     DTGDLELPGE RQQKHEVADR EATMRGGRLQ QDAGLPDPGK GALPSGHCGR PDSETLMEVD
     AAEQSLVAVL SSSVGNGSAS GLTLGNPLME VELPTCSPSS EILNGSIPIQ DLQPPEGSVE
     MPGTDRAYGG RASSSSVCGS SQPPAESAEE SCSSITTALK ELHELLVISS KPASEAAYEE
     VTCQSEGTAW GQTRVNPSER WTESERRTQD EDRPQVSHAI PECVKTEKLT DASPDTRIED
     GENATFQGPG GGLSTDHGAP RSRGSVHESR SVTVTSAETS NQSHRTLGVE ISPRLLTGEG
     DALSQTCEQT KSLLVKDLGQ GTQNPAPDRP ATREDVCRDA ARPSLEVEAP PSHSSGPCIL
     PPLGFPAADI DRILRAGFTL QEALGALHRV GGNADLALLV LLAKNIVVPT