ID   RSD_ECO5E               Reviewed;         158 AA.
AC   B5Z091;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Regulator of sigma D {ECO:0000255|HAMAP-Rule:MF_01181};
GN   Name=rsd {ECO:0000255|HAMAP-Rule:MF_01181};
GN   OrderedLocusNames=ECH74115_5464;
OS   Escherichia coli O157:H7 (strain EC4115 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=444450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC4115 / EHEC;
RX   PubMed=22135463; DOI=10.1073/pnas.1107176108;
RA   Eppinger M., Mammel M.K., Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Genomic anatomy of Escherichia coli O157:H7 outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20142-20147(2011).
CC   -!- FUNCTION: Binds RpoD and negatively regulates RpoD-mediated
CC       transcription activation by preventing the interaction between the
CC       primary sigma factor RpoD with the catalytic core of the RNA polymerase
CC       and with promoter DNA. May be involved in replacement of the RNA
CC       polymerase sigma subunit from RpoD to RpoS during the transition from
CC       exponential growth to the stationary phase. {ECO:0000255|HAMAP-
CC       Rule:MF_01181}.
CC   -!- SUBUNIT: Interacts with RpoD. {ECO:0000255|HAMAP-Rule:MF_01181}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01181}.
CC   -!- SIMILARITY: Belongs to the Rsd/AlgQ family. {ECO:0000255|HAMAP-
CC       Rule:MF_01181}.
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DR   EMBL; CP001164; ACI35720.1; -; Genomic_DNA.
DR   RefSeq; WP_000934302.1; NC_011353.1.
DR   AlphaFoldDB; B5Z091; -.
DR   SMR; B5Z091; -.
DR   GeneID; 66672093; -.
DR   KEGG; ecf:ECH74115_5464; -.
DR   HOGENOM; CLU_142729_0_0_6; -.
DR   OMA; DVIDHWL; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.20.120.1370; -; 1.
DR   HAMAP; MF_01181; Rsd; 1.
DR   InterPro; IPR038309; Rsd/AlgQ_sf.
DR   InterPro; IPR023785; Sigma70_reg_Rsd.
DR   InterPro; IPR007448; Sigma70_reg_Rsd_AlgQ.
DR   Pfam; PF04353; Rsd_AlgQ; 1.
DR   PIRSF; PIRSF016548; Rsd_AlgQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Transcription; Transcription regulation.
FT   CHAIN           1..158
FT                   /note="Regulator of sigma D"
FT                   /id="PRO_1000138189"
SQ   SEQUENCE   158 AA;  18243 MW;  BDB699DAC440A808 CRC64;
     MLNQLDNLTE RVRGSNKLVD RWLHVRKHLL VAYYNLVGIK PGKESYMRLN EKALDDFCQS
     LVDYLSAGHF SIYERILHKL EGNGQLARAA KIWPQLEANT QQIMDYYDSS LETAIDHDNY
     LEFQQVLSDI GEALEARFVL EDKLILLVLD AARVKHPA