RSD_ECOL6
ID RSD_ECOL6 Reviewed; 158 AA.
AC Q8FB76;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Regulator of sigma D {ECO:0000255|HAMAP-Rule:MF_01181};
GN Name=rsd {ECO:0000255|HAMAP-Rule:MF_01181}; OrderedLocusNames=c4952;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Binds RpoD and negatively regulates RpoD-mediated
CC transcription activation by preventing the interaction between the
CC primary sigma factor RpoD with the catalytic core of the RNA polymerase
CC and with promoter DNA. May be involved in replacement of the RNA
CC polymerase sigma subunit from RpoD to RpoS during the transition from
CC exponential growth to the stationary phase. {ECO:0000255|HAMAP-
CC Rule:MF_01181}.
CC -!- SUBUNIT: Interacts with RpoD. {ECO:0000255|HAMAP-Rule:MF_01181}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01181}.
CC -!- SIMILARITY: Belongs to the Rsd/AlgQ family. {ECO:0000255|HAMAP-
CC Rule:MF_01181}.
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DR EMBL; AE014075; AAN83380.1; -; Genomic_DNA.
DR RefSeq; WP_000934299.1; NC_004431.1.
DR AlphaFoldDB; Q8FB76; -.
DR SMR; Q8FB76; -.
DR STRING; 199310.c4952; -.
DR EnsemblBacteria; AAN83380; AAN83380; c4952.
DR KEGG; ecc:c4952; -.
DR eggNOG; COG3160; Bacteria.
DR HOGENOM; CLU_142729_0_0_6; -.
DR OMA; DVIDHWL; -.
DR BioCyc; ECOL199310:C4952-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.20.120.1370; -; 1.
DR HAMAP; MF_01181; Rsd; 1.
DR InterPro; IPR038309; Rsd/AlgQ_sf.
DR InterPro; IPR023785; Sigma70_reg_Rsd.
DR InterPro; IPR007448; Sigma70_reg_Rsd_AlgQ.
DR Pfam; PF04353; Rsd_AlgQ; 1.
DR PIRSF; PIRSF016548; Rsd_AlgQ; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Transcription; Transcription regulation.
FT CHAIN 1..158
FT /note="Regulator of sigma D"
FT /id="PRO_0000268882"
SQ SEQUENCE 158 AA; 18195 MW; 90B699DAD0C67371 CRC64;
MLNQLDNLTE RVRGSNKLVD RWLHVRKHLL VAYYNLVGIK PGKESYMRLN EKALDDFCQS
LVDYLSAGHF SIYERILHKL EGNGQLARAA KIWPQLEANT QQIMDDYDSS LETAIDHDNY
LEFQQVLSDI GEALEARFVL EDKLILLVLD AARVKHPA