ID   BBS5_XENLA              Reviewed;         365 AA.
AC   Q66IS6;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog;
GN   Name=bbs5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000305}.
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DR   EMBL; BC081218; AAH81218.1; -; mRNA.
DR   RefSeq; NP_001087782.1; NM_001094313.2.
DR   AlphaFoldDB; Q66IS6; -.
DR   SMR; Q66IS6; -.
DR   DNASU; 447606; -.
DR   GeneID; 447606; -.
DR   KEGG; xla:447606; -.
DR   CTD; 447606; -.
DR   Xenbase; XB-GENE-965970; bbs5.L.
DR   OrthoDB; 1257336at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447606; Expressed in intestine and 19 other tissues.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; DM16_repeat.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351; PTHR21351; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome.
FT   CHAIN           1..365
FT                   /note="Bardet-Biedl syndrome 5 protein homolog"
FT                   /id="PRO_0000223258"
SQ   SEQUENCE   365 AA;  41897 MW;  DAC914D9BABBA342 CRC64;
     MLSVLDALWE DRDVRFDISP QQMKMRPGEV LIDCLDSIED TKGNNGDRGR LLVTNLRVIW
     HSLALPRVNL AVGYNCIINI TTRTANSKLR GQTEALYILT KCNNTRFEFI FTNLVPGSPR
     LFTSVIAVHR AYETSKMYRD LKLRGALIQN KQLKLLPREQ VYDKINGVWN LSSDQGNLGT
     FFITNVRIVW HANMNDSFNV SIPYLQIRSI KIRDSKFGLA LVIESSQQSG GYVLGFKIDP
     VEKLQDSVKE INSLHRVYSA SPIFGVEYEM EEKPQALEEL TIEQVQDDVE IEADEHTDAF
     VVSRLSRISY FTRQIIYILI FTRMYSGWFH HSLTKLHGSI RFNSVTIAAD FLYIYISQNG
     TKIVK