ID   RSE1_ASHGO              Reviewed;        1288 AA.
AC   Q753D4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Pre-mRNA-splicing factor RSE1;
GN   Name=RSE1; OrderedLocusNames=AFR382W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 1128-1129.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RSE1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53753.2; -; Genomic_DNA.
DR   RefSeq; NP_985929.2; NM_211284.2.
DR   AlphaFoldDB; Q753D4; -.
DR   SMR; Q753D4; -.
DR   STRING; 33169.AAS53753; -.
DR   EnsemblFungi; AAS53753; AAS53753; AGOS_AFR382W.
DR   GeneID; 4622200; -.
DR   KEGG; ago:AGOS_AFR382W; -.
DR   eggNOG; KOG1898; Eukaryota.
DR   HOGENOM; CLU_003246_0_1_1; -.
DR   InParanoid; Q753D4; -.
DR   OMA; FFLVQTE; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..1288
FT                   /note="Pre-mRNA-splicing factor RSE1"
FT                   /id="PRO_0000218625"
FT   REGION          725..744
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..739
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1288 AA;  144813 MW;  18ED7D13D7989FB5 CRC64;
     MNEKEELHLY HVSLQKQRNY VHSCIGHFVD YRHHHIRAQG GSVEGGKKGS KWRKQLQICM
     ATQTQVELYD VEEGRLRRLF TRTVFGTITG LSSVVADGRS VLIVVGDSGK MSVLRFKYEG
     GRVRLEALFN EPLSRSGVRR LSPQAHVSVD PQGRCVLLSA MERNKVCYLM DVKQGELQVS
     SPLEANRPNY VTMQTAACDV AFDNPIFASL EIDLADGAKY LFFYMLDLGL NHMAKVADFE
     LGDGSANFIM SVPDLEQYGI NTKAGGPDDG DPDAIVPFVL MGFDNYVSLK DLRGRYDINV
     QIPTRKLSQK TIITAGTVQK LKRDFFMLLQ SNHGDLYKVK ILPDEKTASP VVTISYFDTI
     PQAQNLHIFK HGYMFANSEY GNSYLYQFEN LDDEEESMLT SVMPGRRLII EPRTVLKNLL
     VADKLALVNP ILSSQLTERV PLTIATSTLG DVRLFTAGVN FMDIISSPLP AAPLDIWTVA
     TNGSRFHKLL FIALQESTMI LKIAAGTVEE LELPHNPFVI AQDKTVLIAH MGGQSIIQVT
     ENKMVHIIEN RDESYESKLE WFPPAGICIL KASSNSTQLI LALSNNEVVY FEIGSNESLN
     ELQDRIEVEE RITALAIGNG NRSDYMIIAS VDSTVKVYSL KVQDQANFLE VVSMQVLVSP
     ASSLQLASSG GSLCLHIGLD SGVYVRSKLD RNTGELFDVR TKYLGTKPVE ISLLLDMNPY
     INEEVDDEGE EEEEQDDEES LGGPHSRLVP CVVLHSGKTW ISYELDSSLF IRPLLNDQSL
     KRVAQFTSNE IQRNGCCSIS SAGFLVIGRI GTFRNNDCWF QESSLALPDS EDSVNGNELE
     NDEKDPDALL EEKQKVNSSI GKLIIPDPDD IKLFYYCEYN EVENSCRVSL FKQGISYKHE
     NSTEAFQLIP DCRPSTATIA RFGLDMKHLV ISTVNGVLKT FVIRITKAAN NRRFELLALH
     DTVAGSTIHA MCPFHDKLLV PLANAVVLYG LGKKQLLKKS ISYLPTSITK IVALDQWNGT
     RVAVGDIHES VTLLHFDERK NQFIPVADDV TKRHVTVVKF VDECTVIGGD RFGNIWLLRL
     PLEYDRLIKE GVDSYLLTLN TGIPSNIREC VFKWQLLNHF YINDIPMSFH LIASPQMADR
     ASILYAGLQG TIGYLIPLIT RREIEFFDLL EQAMRDADHL FYLDQENRLN DTSELNDGAD
     EEGSVIDRRF PSVQKKRKIP EGAYSLVGRD AMMYRSYYNP VRHVTDGDLC EQFLELYPSE
     KNFLAARVDN RSVQEIERRI NDMRTNCM