ID   RSE1_CRYNJ              Reviewed;        1217 AA.
AC   P0CR22; Q55ZR3; Q5KP25;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Pre-mRNA-splicing factor RSE1;
GN   Name=RSE1; OrderedLocusNames=CNA04430;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RSE1 family. {ECO:0000305}.
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DR   EMBL; AE017341; AAW40985.1; -; Genomic_DNA.
DR   RefSeq; XP_566804.1; XM_566804.1.
DR   AlphaFoldDB; P0CR22; -.
DR   SMR; P0CR22; -.
DR   STRING; 5207.AAW40985; -.
DR   PaxDb; P0CR22; -.
DR   EnsemblFungi; AAW40985; AAW40985; CNA04430.
DR   GeneID; 3253342; -.
DR   KEGG; cne:CNA04430; -.
DR   VEuPathDB; FungiDB:CNA04430; -.
DR   eggNOG; KOG1898; Eukaryota.
DR   HOGENOM; CLU_003246_0_0_1; -.
DR   InParanoid; P0CR22; -.
DR   OMA; FFLVQTE; -.
DR   OrthoDB; 97116at2759; -.
DR   Proteomes; UP000002149; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..1217
FT                   /note="Pre-mRNA-splicing factor RSE1"
FT                   /id="PRO_0000218629"
SQ   SEQUENCE   1217 AA;  134097 MW;  B110309F1EDBA73A CRC64;
     MHLLNLTLSS PTNVSTAVVG SFSGSKSQEI LCVRGGTKLE IFKLNATTGQ LDTIVSTEAF
     GTIRNIAGFR LAGMTKDYIL ATSDSGRLSI LEFVISPTPH FESLYQEVFG KSGSRRIVPG
     QFLAVDPKGR SCLVGSLEKT KLVYVLNRNT EGKLYPSSPL EAHKNHTLVT HIVGVDQGYD
     NPLYAALETD YSESDQDSTG EAYENTQKHL TFYELDLGLN HVVRKWSEPT DRRANLLVQV
     PGGQNANSDR FEGPSGVLVC TEDHIIWKHM DVEAHRIPIP RRRNPLVQRG DKSRGLIIVS
     AVMHKIKGAF FFLLQSEDGD LYKVWIEHNG EDVVALKIKY FDTVPVANSL CILKRGYIYV
     ASEFSDQNLY QFQSLAEDDG EQEWSSTDYP ENGNIDGPLP FAFFDPQPLR NLLLVDTVPS
     LDPITDAHVV NLLGASSDTP QIYAACGRGA RSTFRTLKHG LDVAEMVSSP LPGVPTNVWT
     LKLTEDDEYD SYIVLSFPNG TLVLSIGETI EEVNDTGFLS SGPTLAVQQL GNAGLLQVHP
     YGLRHIRAAD RVDEWPAPPG QTIVAATTNR RQVVIALSTA ELVYFELDPE GSLSEYQEKK
     ALPGNATCVT IAEVPEGRRR TSFLAVGCDN QTVSIISLEP DSTLDTLSLQ ALTAPPTSIC
     LAEIFDTSID KNRATMFLNI GLMNGVLLRT VVDPVDGSLS DTRLRFLGAK PPKLVRANVQ
     GQPSVMAFSS RTWLLYTYQD MLQTQPLIYD TLEYAWSLSA AMCPDGLIGI SGNTLRIFNI
     PKLGEKLKQD STALTYTPRK FISHPFNSVF YMIEADHRTY SKSAIERIVK QKESEGRRVD
     TLLLDLPANE FGRPRAPAGH WASCVRVLDP LANETIMTLD LDEDEAAFSI AIAYFERGGG
     EPFLVVGTGV KTTLQPKGCK EGYLRVYAIK EQGRILEFLH KTKTDDIPLC LAGFQGFLLA
     GIGKSLRLYE MGKKALLRKC ENNGFPTAVV TINVQGARII VGDMQESTFY CVYRSIPTRQ
     LLIFADDSQP RWITCVTSVD YETVACGDKF GNIFINRLDP SISEKVDDDP TGATILHEKS
     FLMGAAHKTE MIGHYNIGSV VTSITKIPLV AGGRDVLVYT TISGAVGALV PFVSSDDIEF
     MSTLEMHMRT QDISLVGRDH IAYRGYYVPI KGVVDGDLCE SFSLLPYPKQ QAIALDLDRS
     VGDVLKKLEQ MRTSSAF