ID   RSE1_KLULA              Reviewed;        1269 AA.
AC   Q6CXH8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Pre-mRNA-splicing factor RSE1;
GN   Name=RSE1; OrderedLocusNames=KLLA0A08129g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RSE1 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02949.1; -; Genomic_DNA.
DR   RefSeq; XP_451361.1; XM_451361.1.
DR   AlphaFoldDB; Q6CXH8; -.
DR   SMR; Q6CXH8; -.
DR   STRING; 28985.XP_451361.1; -.
DR   PRIDE; Q6CXH8; -.
DR   EnsemblFungi; CAH02949; CAH02949; KLLA0_A08129g.
DR   GeneID; 2896375; -.
DR   KEGG; kla:KLLA0_A08129g; -.
DR   eggNOG; KOG1898; Eukaryota.
DR   HOGENOM; CLU_003246_0_0_1; -.
DR   InParanoid; Q6CXH8; -.
DR   OMA; FFLVQTE; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005686; C:U2 snRNP; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0030620; F:U2 snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..1269
FT                   /note="Pre-mRNA-splicing factor RSE1"
FT                   /id="PRO_0000218632"
SQ   SEQUENCE   1269 AA;  142995 MW;  4D1C6AD7F61842F8 CRC64;
     MTQDSEVLLW HTVLQRHRNY VHSCIGDFTL DRSSLATAEA DTTSVKGPRS SKKRKELQLC
     LATQDCVELY DVSNGTLDAL GKWPIAATIL SMTKLNMDRC SHTILVLITD SGNLTFWQFE
     RDSVSGKVYV RTLANEPISR SGIRRFVPQY QMVSDPQSRC VFFSGIERSK MCVLADWQRG
     KLVVGSPIEI QRSDRITLAS AACDVSFDNP VNAAIEVESG TNDYYLSFYT MDLGLNTLLL
     RKEHLLEDKS INFVMQCPNL QQYKIKTRPN DETDQDSVNP FVICGYDGYL TLIDLEGFYE
     VSVQLPVRKT VSSTNIINGT IHKLKKDFFI LMQSNHGDMY KVGIIPDEET KAPVLEIAYF
     DTLPTSEDIH IFKSGALFNV SEFGTSYLTQ FESLGEDLEK ITSYTPGRRS FIETESTLKN
     LSILDSLTSL NPLTSFHASN STPLTILAAA NQTENLVKLT SAVDFEELIS TTLPRIPSKL
     WTVRIPKNET HSLIFLSMET STTILKIHEG TVEDFGGDSN PFILNKPSLF VGAMVQRSII
     QVTRDCLLQI IEMHDGPYTK KLEWYPPAGV GIVTAFCNET QLVVALTNHE ICYFEIIEDS
     LNELQDRVEM DSTVNSIALL AGQKSGYCVL GCEDSSLQIL NLQSKHPDFF TICAIQSLIS
     KPHSLLFMRD TSDLKIHVGM KSGVYLSSKL NINDGTVFDV RTRFVGTKPV QVNLLDNIDI
     NHKDDDDDEP GENDSKIDDF KKKISDFTPL VVLNSSISWV TYEIDDKITL RPLKTDEGIT
     LKHINAFITD DIKRNGCCSI TSKGQLLIGK LDNFLSWSNW FNEKKYTLVN DELKNAGNEE
     EDEDEDEDED EDASEKYEIV GYQSQRILSD TTDNSLSYVI SKTANKETSL SAIRDDKLLA
     TNNGNTVVII AKEVFNAVCS CNFGTNVKYI VISTESGKFI VIQIRVKNNV LETQYIHETM
     VHSKVNAMVS FGDKLACCIL GNVVLFGLGK KQLLRKSITE MPPYITQVTA LDQWDGTMLA
     VGDIRESVTI FKYDIDNNSF IGVADDIVKR HVTTVKFIDV SSVIGGDRFG NCWVLRVNYE
     SDTRVASNIK ACQYTLETLC HMYMNDTPMK FEIVNHMNMS DRPAILWIGL QGTIGCFVPL
     ITRKEQQLYQ SFQSTYAELD VLHFQDNNKP EEVDLEETEG ALDEAYHTTK NTDHQDYVEG
     VISRVGRDFL SYRSSYAPSK NIIDGETLEQ LTTYLPSDQR WIASKMKHAD SGKLDIFNKY
     INEMRTNYV