BBS_PHASS
ID BBS_PHASS Reviewed; 390 AA.
AC P53416; O24477;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Bibenzyl synthase;
DE EC=2.3.1.-;
GN Name=BIBSY212; Synonyms=PCS1;
OS Phalaenopsis sp. (Moth orchid).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae;
OC Epidendroideae; Vandeae; Aeridinae; Phalaenopsis;
OC unclassified Phalaenopsis.
OX NCBI_TaxID=36900;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7872785; DOI=10.1006/abbi.1995.1154;
RA Preisig-Mueller R., Gnau P., Kindl H.;
RT "The inducible 9, 10-dihydrophenanthrene pathway: characterization and
RT expression of bibenzyl synthase and S-adenosylhomocysteine hydrolase.";
RL Arch. Biochem. Biophys. 317:201-207(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. True Lady; TISSUE=Petal;
RA Hsu W.-S., Do Y.-Y., Huang P.-L.;
RT "Isolation and characterization of a cDNA encoding chalcone synthase
RT homolog from Phalaenopsis.";
RL (er) Plant Gene Register PGR97-068(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA =
CC 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA; Xref=Rhea:RHEA:47608,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:87803, ChEBI:CHEBI:87804;
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; X79903; CAA56276.1; -; mRNA.
DR EMBL; X79904; CAA56277.1; -; mRNA.
DR EMBL; U88077; AAB65094.1; -; mRNA.
DR PIR; S71619; S71619.
DR PIR; S71620; S71620.
DR AlphaFoldDB; P53416; -.
DR SMR; P53416; -.
DR PRIDE; P53416; -.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Flavonoid biosynthesis; Transferase.
FT CHAIN 1..390
FT /note="Bibenzyl synthase"
FT /id="PRO_0000216090"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
FT VARIANT 2
FT /note="L -> P"
FT CONFLICT 5
FT /note="E -> D (in Ref. 2; AAB65094)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="A -> S (in Ref. 2; AAB65094)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="S -> R (in Ref. 2; AAB65094)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 390 AA; 42532 MW; F34AE240318FD4F1 CRC64;
MLSLESIKKA PRADGFASIL AIGRANPDNI IEQSAYPDFY FRVTNSEHLV DLKKKFQRIC
EKTAIRKRHF VWNEEFLTAN PCFSTFMDKS LNVRQEVAIS EIPKLGAKAA TKAIEDWGQP
KSRITHLIFC TTSGMDLPGA DYQLTQILGL NPNVERVMLY QQGCFAGGTT LRLAKCLAES
RKGARVLVVC AETTTVLFRA PSEEHQDDLV TQALFADGAS AVIVGADPDE AADERASFVI
VSTSQVLLPD SAGAIGGHVS EGGLLATLHR DVPQIVSKNV GKCLEEAFTP FGISDWNSIF
WVPHPGGRAI LDQVEERVGL KPEKLSVSRH VLAEYGNMSS VCVHFALDEM RKRSANEGKA
TTGEGLEWGV LFGFGPGLTV ETVVLRSVPL
