RSF1_YEAST
ID RSF1_YEAST Reviewed; 376 AA.
AC Q05043; D6VZK4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Respiration factor 1;
GN Name=RSF1; OrderedLocusNames=YMR030W; ORFNames=YM9973.03;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12734673; DOI=10.1007/s00294-003-0398-z;
RA Lu L., Roberts G., Simon K., Yu J., Hudson A.P.;
RT "Rsf1p, a protein required for respiratory growth of Saccharomyces
RT cerevisiae.";
RL Curr. Genet. 43:263-272(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP FUNCTION.
RX PubMed=16464826; DOI=10.1093/nar/gkj493;
RA Titz B., Thomas S., Rajagopala S.V., Chiba T., Ito T., Uetz P.;
RT "Transcriptional activators in yeast.";
RL Nucleic Acids Res. 34:955-967(2006).
RN [7]
RP FUNCTION.
RX PubMed=17003135; DOI=10.1073/pnas.0508637103;
RA Yu H., Gerstein M.;
RT "Genomic analysis of the hierarchical structure of regulatory networks.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:14724-14731(2006).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Mitochondrial and nuclear transcriptional activator required
CC for respiratory growth. {ECO:0000269|PubMed:12734673,
CC ECO:0000269|PubMed:16464826, ECO:0000269|PubMed:17003135}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion.
CC -!- INDUCTION: During respiratory growth. {ECO:0000269|PubMed:12734673}.
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DR EMBL; Z49213; CAA89145.1; -; Genomic_DNA.
DR EMBL; AY557995; AAS56321.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09928.1; -; Genomic_DNA.
DR PIR; S53946; S53946.
DR RefSeq; NP_013743.1; NM_001182526.1.
DR AlphaFoldDB; Q05043; -.
DR SMR; Q05043; -.
DR BioGRID; 35202; 152.
DR DIP; DIP-4817N; -.
DR STRING; 4932.YMR030W; -.
DR iPTMnet; Q05043; -.
DR MaxQB; Q05043; -.
DR PaxDb; Q05043; -.
DR PRIDE; Q05043; -.
DR EnsemblFungi; YMR030W_mRNA; YMR030W; YMR030W.
DR GeneID; 855045; -.
DR KEGG; sce:YMR030W; -.
DR SGD; S000004632; RSF1.
DR VEuPathDB; FungiDB:YMR030W; -.
DR HOGENOM; CLU_736105_0_0_1; -.
DR OMA; RRTKRIC; -.
DR BioCyc; YEAST:G3O-32735-MON; -.
DR PRO; PR:Q05043; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q05043; protein.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0009060; P:aerobic respiration; IMP:SGD.
DR GO; GO:0006390; P:mitochondrial transcription; IMP:SGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:SGD.
DR InterPro; IPR027998; Rsf1_fungi.
DR Pfam; PF14876; RSF; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; Mitochondrion; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..376
FT /note="Respiration factor 1"
FT /id="PRO_0000203272"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 43460 MW; 9C63E0BE73010A23 CRC64;
MKDLNPEMGK FATTKGPPQD NRGMVDIATL PNFPANRSGT PREEMYLAPN KMETPRILNM
NMVPDYLQKE NFSPDFSSAT VSAKSSPVNV THDESLPLGT IESNSTKDSK YAVQRQQQQV
VDFIENNMQL LSSETLNFRS DIMKTLELPI PKRRDIKGNH LSKLLFAKSP LTINTYCQFY
DRRTKRICNQ EMIWKDKNSR EKHGSRKYQR HLSKVHDVQL TPNNFTEFFD HNSPLFQECY
DYQSRLMRDL LVEPDAKFKE KKKKKKGDVN GNHPETGSSL INHQVQQQNV RELQSKIAMN
DLIEILIDLN IPFSVLDYQP MRNWLIKYSI ISTDTLPDEV YFKTDPGVNE LEHNSSNLNN
SNSGTPHNHN QNQHTN
