ID   RSFA_MYCTO              Reviewed;         128 AA.
AC   P9WGE2; L0T9F0; Q11035;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Anti-sigma-F factor antagonist RsfA;
DE   AltName: Full=Anti-anti-sigma F factor RsfA;
GN   Name=rsfA; OrderedLocusNames=MT1411;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Positive, redox-sensitive regulator of sigma-F (SigF)
CC       activity. When reduced binds to anti-sigma-F factor RsbW (UsfX)
CC       preventing its binding to SigF, thus activating transcription (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with anti-sigma-F factor RsbW (UsfX) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45674.1; -; Genomic_DNA.
DR   PIR; D70742; D70742.
DR   RefSeq; WP_003898845.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGE2; -.
DR   SMR; P9WGE2; -.
DR   EnsemblBacteria; AAK45674; AAK45674; MT1411.
DR   GeneID; 45425345; -.
DR   KEGG; mtc:MT1411; -.
DR   PATRIC; fig|83331.31.peg.1517; -.
DR   HOGENOM; CLU_115403_5_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR003658; Anti-sigma_ant.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   Pfam; PF01740; STAS; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00377; ant_ant_sig; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Transcription; Transcription regulation.
FT   CHAIN           1..128
FT                   /note="Anti-sigma-F factor antagonist RsfA"
FT                   /id="PRO_0000428377"
FT   DOMAIN          17..128
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT   DISULFID        73..109
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  13589 MW;  BB489351860A0005 CRC64;
     MNPTQAGSFT TPVSNALKAT IQHHDSAVII HARGEIDAAN EHTWQDLVTK AAAATTAPEP
     LVVNLNGLDF MGCCAVAVLA HEAERCRRRG VDVRLVSRDR AVARIIHACG YGDVLPVHPT
     TESALSAT