ID   RSFB_MYCTO              Reviewed;         122 AA.
AC   P9WGE0; F2GFD0; O69655; Q7D525;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Anti-sigma-F factor antagonist RsfB;
DE   AltName: Full=Anti-anti-sigma F factor RsfB;
GN   Name=rsfB; OrderedLocusNames=MT3789;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Positive regulator of sigma-F (SigF) activity. Binds to anti-
CC       sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus
CC       activating transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with anti-sigma-F factor RsbW (UsfX). Its
CC       phosphorylation may prevent this interaction (By similarity).
CC       {ECO:0000250}.
CC   -!- PTM: Putative phosphorylation on Ser-61 may prevent interaction with
CC       RsbW. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK48156.1; -; Genomic_DNA.
DR   PIR; H70791; H70791.
DR   RefSeq; WP_003419762.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGE0; -.
DR   SMR; P9WGE0; -.
DR   EnsemblBacteria; AAK48156; AAK48156; MT3789.
DR   GeneID; 45427684; -.
DR   KEGG; mtc:MT3789; -.
DR   PATRIC; fig|83331.31.peg.4080; -.
DR   HOGENOM; CLU_115403_3_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR003658; Anti-sigma_ant.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   Pfam; PF01740; STAS; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00377; ant_ant_sig; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Transcription; Transcription regulation.
FT   CHAIN           1..122
FT                   /note="Anti-sigma-F factor antagonist RsfB"
FT                   /id="PRO_0000428378"
FT   DOMAIN          7..115
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT   MOD_RES         61
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   122 AA;  12651 MW;  3F748FC41C6CCBB7 CRC64;
     MSAPDSITVT VADHNGVAVL SIGGEIDLIT AAALEEAIGE VVADNPTALV IDLSAVEFLG
     SVGLKILAAT SEKIGQSVKF GVVARGSVTR RPIHLMGLDK TFRLFSTLHD ALTGVRGGRI
     DR