RSFR_CHICK
ID RSFR_CHICK Reviewed; 139 AA.
AC P30374;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Ribonuclease homolog;
DE EC=3.1.27.-;
DE AltName: Full=RSFR;
DE Flags: Precursor;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone marrow;
RX PubMed=1599460; DOI=10.1016/s0006-291x(05)80980-5;
RA Klenova E.M., Botezato I., Laudet V., Goodwin G.H., Wallace J.C.,
RA Lobanenkov V.V.;
RT "Isolation of a cDNA clone encoding the RNase-superfamily-related gene
RT highly expressed in chicken bone marrow cells.";
RL Biochem. Biophys. Res. Commun. 185:231-239(1992).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; X64743; CAA46006.1; -; mRNA.
DR PIR; JH0615; JH0615.
DR RefSeq; NP_001007943.1; NM_001007942.1.
DR AlphaFoldDB; P30374; -.
DR SMR; P30374; -.
DR STRING; 9031.ENSGALP00000033366; -.
DR Ensembl; ENSGALT00000034008; ENSGALP00000033366; ENSGALG00000027165.
DR GeneID; 423668; -.
DR KEGG; gga:423668; -.
DR CTD; 423668; -.
DR VEuPathDB; HostDB:geneid_423668; -.
DR eggNOG; ENOG502T1FH; Eukaryota.
DR GeneTree; ENSGT00940000166697; -.
DR HOGENOM; CLU_117006_3_1_1; -.
DR OMA; NDRSYCN; -.
DR OrthoDB; 1549558at2759; -.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR Reactome; R-GGA-6803157; Antimicrobial peptides.
DR PRO; PR:P30374; -.
DR Proteomes; UP000000539; Chromosome 6.
DR Bgee; ENSGALG00000027165; Expressed in spleen and 12 other tissues.
DR ExpressionAtlas; P30374; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004540; F:ribonuclease activity; IMP:AgBase.
DR GO; GO:0001525; P:angiogenesis; IDA:AgBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:AgBase.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023411; RNaseA_AS.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
DR PROSITE; PS00127; RNASE_PANCREATIC; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..139
FT /note="Ribonuclease homolog"
FT /id="PRO_0000030860"
FT ACT_SITE 34
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 133
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 65..69
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT DISULFID 49..102
FT /evidence="ECO:0000250"
FT DISULFID 64..111
FT /evidence="ECO:0000250"
FT DISULFID 82..126
FT /evidence="ECO:0000250"
SQ SEQUENCE 139 AA; 15948 MW; 0970A59F786BF74C CRC64;
MAMSSLWWTA ILLLALTVSM CYGVPTYQDF LYKHMDFPKT SFPSNAAYCN VMMVRRGMTA
HGRCKSFNTF VHTDPRNLNT LCINQPDQAL RTTRRHFRIT DCKLIRSHPT CRYSGNQFNR
RVRVGCRGGL PVHLDGTSP
