ID   BBUR_BORBR              Reviewed;         325 AA.
AC   O06703;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=HTH-type transcriptional regulator BbuR;
GN   Name=bbuR; OrderedLocusNames=BB4328;
OS   Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS   (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB7866;
RX   PubMed=9524276; DOI=10.1016/s0378-1119(97)00651-3;
RA   McMillan D.J., Mau M., Walker M.J.;
RT   "Characterisation of the urease gene cluster in Bordetella
RT   bronchiseptica.";
RL   Gene 208:243-251(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC46123.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF000579; AAC46123.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; BX640450; CAE34691.1; -; Genomic_DNA.
DR   RefSeq; WP_003814834.1; NC_002927.3.
DR   AlphaFoldDB; O06703; -.
DR   SMR; O06703; -.
DR   STRING; 257310.BB4328; -.
DR   PRIDE; O06703; -.
DR   EnsemblBacteria; CAE34691; CAE34691; BB4328.
DR   GeneID; 56477173; -.
DR   KEGG; bbr:BB4328; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_5_4; -.
DR   OMA; LSMGITH; -.
DR   OrthoDB; 990666at2; -.
DR   Proteomes; UP000001027; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="HTH-type transcriptional regulator BbuR"
FT                   /id="PRO_0000105593"
FT   DOMAIN          15..72
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   325 AA;  34987 MW;  8720CA118CF86EC3 CRC64;
     MAAEDFALPA DHNPLDTDLL NVFCWVAKTQ SFSRAAAELG TSQPVITRKI GRLEECLGVA
     LFVRSNRGCV LTAAGTVLIG KAPSILLQLA EIKEEVSHSA SVVSGSLSMG ITHAASTVMA
     PRLLPVIARR WPKLQVDVME ALSRTLVERV LHGELALAVL FDPPPHPDLI CRPLLIERLC
     LVGNPQSDLR TMAPPTIRDL ARLPLMLPSG GQIIRNLLED AFAEINEPLK PVYEAASMAM
     LREMAVQGIG YTLLTQGGVA EDVAAGKLIA QALPDKGMVV TLTLITKRES TRLRNVRLLS
     DFVASEIRAV ARQGQWPGHP TVVGG