ABCCA_DICDI
ID ABCCA_DICDI Reviewed; 1334 AA.
AC Q8ST87; Q54U42;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=ABC transporter C family member 10;
DE AltName: Full=ABC transporter ABCC.10;
GN Name=abcC10; ORFNames=DDB_G0280977;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AF474342; AAL85713.1; -; Genomic_DNA.
DR EMBL; AAFI02000040; EAL66785.1; -; Genomic_DNA.
DR RefSeq; XP_640934.1; XM_635842.1.
DR AlphaFoldDB; Q8ST87; -.
DR SMR; Q8ST87; -.
DR STRING; 44689.DDB0215367; -.
DR PaxDb; Q8ST87; -.
DR PRIDE; Q8ST87; -.
DR EnsemblProtists; EAL66785; EAL66785; DDB_G0280977.
DR GeneID; 8622997; -.
DR KEGG; ddi:DDB_G0280977; -.
DR dictyBase; DDB_G0280977; abcC10.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_1_1; -.
DR InParanoid; Q8ST87; -.
DR OMA; MNNYSAR; -.
DR PhylomeDB; Q8ST87; -.
DR Reactome; R-DDI-189483; Heme degradation.
DR Reactome; R-DDI-2142691; Synthesis of Leukotrienes (LT) and Eoxins (EX).
DR Reactome; R-DDI-2142850; Hyaluronan biosynthesis and export.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-9707564; Cytoprotection by HMOX1.
DR Reactome; R-DDI-9748787; Azathioprine ADME.
DR Reactome; R-DDI-9749641; Aspirin ADME.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR Reactome; R-DDI-9754706; Atorvastatin ADME.
DR Reactome; R-DDI-9758890; Transport of RCbl within the body.
DR PRO; PR:Q8ST87; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1334
FT /note="ABC transporter C family member 10"
FT /id="PRO_0000363855"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 718..738
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 843..863
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 865..885
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 958..978
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 984..1004
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 105..391
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 423..647
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 726..1016
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1053..1287
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 459..466
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1087..1094
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1334 AA; 149289 MW; B29253642F2B32E8 CRC64;
MKEIELDRPE EKKKKVKKEK KIGYGGKKSP EENSNFLSNL TFSWADGFVI HCFRNVLQLS
HLWDLASYDK SEYLAKKIAK SWEIEIQKPK PSYLRAGFRA FGKLQLLSIF LYAISVGIQF
VGPEILGRMV TFVVESKLGT STEDPNMGYY YALIMFGTAM IGSFCTYHAN RISFRTGDRL
RSIIVLDVYK KAIKLSNSAR SDTSPGQIVN LMSNDAQRMV EVFGMFNNGA LALPQIIICL
ALLYKKIGWP TFVGLGLMLA AIPFNGMAAK KLTETRKYLV SLSDSRVKAT NEILQAIKII
KLYAWEDSFA KKVIEHRNNE IKLLFSYSRY RTILIVIISA LPTAAAILVI SSYYGHEKSL
DASRIFSALS YLNLLRLPLG FLPIIIALGI QMQIAGKRVT DFLLLPEMKD IQQIDNPSLP
NGVYMKNSTT TWNKLKEDSF GLKNINFEAT GTSLTMVVGS VGSGKSTLVQ AMLGELEIID
GEIGIKGSIA YVPQQAWIIN ATLKENIIFG KELDEERYQK VLEVCALKRD IELFPQGDSV
EIGERGINLS GGQKQRVSIA RAVYSDADVY ILDDPLSAVD SHVGKHLFHK CFKGILSSKT
VILVANQLNY LPFADNTVVL KSGEIVERGT YYELINSKLE FSSILEKYGV DENVISKKDD
IDEDEDEDQD TIEKVEIDLN KDEKSQPKSK SSNTDGTLIS EEESEQGAVA GKVYWKYVTA
GGGLLFLVSM IFFLLETGSK TFSDWWLSHW QTESSERMES ILLGEEPTGL TDDQNLGIYI
GLGMAAVFIS VCKNFIYYEY SVYASRAIHH ELFNALLKKP MYFFDQTPIG RIINRFTRDL
DGIDNLIATS ISTFLTLMLT VIATIILVSI IVPFLLIPLA PISIIFFFLQ YFYRYTSRGL
QRIEAITRSP IFNHFSETLN GVVSIRAYKK QQENILINQK RLDDNNNCYL TLQAMNRWLG
LRLDFLANLI TFFACIFITI DKDTISPANV GLALGYALSL TGNLNYAALQ AADTETKMNS
VERISQYIRG AVEAPQIIDD CRPSPDWPIN GSIKFDNLVM RYREGLDPVL KGITCEIKAK
EKIGIVGRTG AGKSSIVLAL FRLIEASEGS ISIDGENIAK FGLKDLRRNL AIIPQDPVLF
SGTLRENLDP FNERSEEDLF STIEDIQMSA VVKSLEGGLD SKVTENGENF SVGQRQLIVL
ARALLRKPKI LVLDEATASV DGQSDSLIQA TIRNKFSNCT ILTIAHRLNT IMDSDRIMVL
DAGKISEFDE PWTLLQNQNG LLTWLVDETG PQNAIYLRKL AEAKKNGIDI NEIMPIDNET
TPKDNINTPP PPPQ
