ID   BC2_MAGO7               Reviewed;         434 AA.
AC   G4MWA6;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Pyrichalasin H cluster regulator BC2 {ECO:0000303|PubMed:18433432};
DE   AltName: Full=ACE1 cytochalasan biosynthesis cluster protein BC2 {ECO:0000303|PubMed:18433432};
GN   Name=BC2 {ECO:0000303|PubMed:18433432}; ORFNames=MGG_08386;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   FUNCTION, INDUCTION, AND PATHWAY.
RX   PubMed=18433432; DOI=10.1111/j.1469-8137.2008.02459.x;
RA   Collemare J., Pianfetti M., Houlle A.E., Morin D., Camborde L., Gagey M.J.,
RA   Barbisan C., Fudal I., Lebrun M.H., Boehnert H.U.;
RT   "Magnaporthe grisea avirulence gene ACE1 belongs to an infection-specific
RT   gene cluster involved in secondary metabolism.";
RL   New Phytol. 179:196-208(2008).
CC   -!- FUNCTION: Transcription factor probably involved in regulation of gene
CC       cluster that mediates the biosynthesis of a tyrosine-derived
CC       cytochalasan acting as a fungal signal recognized by resistant rice
CC       plants and leads to avirulence in Pi33 resistant rice cultivars.
CC       {ECO:0000269|PubMed:18433432}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expressed exclusively during fungal penetration of host
CC       leaves, the time point at which plant defense reactions are triggered.
CC       {ECO:0000269|PubMed:18433432}.
CC   -!- CAUTION: Due to high divergence, the Zn(2)-C6 fungal-type DNA-binding
CC       domain cannot be predicted. {ECO:0000305}.
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DR   EMBL; CM001232; EHA55866.1; -; Genomic_DNA.
DR   RefSeq; XP_003715673.1; XM_003715625.1.
DR   AlphaFoldDB; G4MWA6; -.
DR   EnsemblFungi; MGG_08386T0; MGG_08386T0; MGG_08386.
DR   GeneID; 2678482; -.
DR   KEGG; mgr:MGG_08386; -.
DR   VEuPathDB; FungiDB:MGG_08386; -.
DR   eggNOG; ENOG502R9RH; Eukaryota.
DR   HOGENOM; CLU_631725_0_0_1; -.
DR   InParanoid; G4MWA6; -.
DR   OrthoDB; 1558353at2759; -.
DR   Proteomes; UP000009058; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..434
FT                   /note="Pyrichalasin H cluster regulator BC2"
FT                   /id="PRO_0000449443"
FT   REGION          297..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  47271 MW;  373DFAB75AA6518B CRC64;
     MEDIGKAGFF SDKSIGTGEN TPLLDSYTFD FDSGPYGGAH YTITGVPDMS TGFSTFAGTG
     LSATEMGYCY PFGVDPSSRG DGSIHPPKCR YEKSIMQVHP ESGDLGMQGA TLFPSSPTSL
     ESVRKRALDL HCFLFTQLHC VTDEDLAEAI LSPFIFSESV KEPTGPRANI IQRLIYASEC
     LLGLISTLSF LWTGCEDSGN SPPASMANQQ GPQFQFPSRT QHKSNSVLAQ HLLGLAGRSL
     HLEDSANFTG RQHTASPSET SVVDLPTITT ILTCHVGILS VYRYTFSRIH DALRACGSSP
     SGTPESELTS PHKRATTCSP LPNKDTLPLN MPFVLGLRVQ LEIMTHMLDR MRAAWATAME
     DHPGHEDHQQ QQEEVKQHDR LSHHKRATLA TLKSMLALNG HELSNQDGGT GIGAVGDLGD
     RVRRLLRNCD KGMY