BCA1_CAEEL
ID BCA1_CAEEL Reviewed; 270 AA.
AC Q22460;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Beta carbonic anhydrase 1;
DE EC=4.2.1.1;
GN Name=bca-1; ORFNames=T13C5.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Reversible hydration of carbon dioxide. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000250|UniProtKB:P45148};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:P45148};
CC -!- SUBUNIT: Oligomer. {ECO:0000250|UniProtKB:P0ABE9}.
CC -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC {ECO:0000255}.
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DR EMBL; FO080546; CCD64556.1; -; Genomic_DNA.
DR PIR; T16868; T16868.
DR RefSeq; NP_741809.1; NM_171701.4.
DR AlphaFoldDB; Q22460; -.
DR SMR; Q22460; -.
DR STRING; 6239.T13C5.5; -.
DR EPD; Q22460; -.
DR PaxDb; Q22460; -.
DR PeptideAtlas; Q22460; -.
DR EnsemblMetazoa; T13C5.5.1; T13C5.5.1; WBGene00000245.
DR GeneID; 180890; -.
DR KEGG; cel:CELE_T13C5.5; -.
DR CTD; 180890; -.
DR WormBase; T13C5.5; CE04946; WBGene00000245; bca-1.
DR eggNOG; KOG1578; Eukaryota.
DR GeneTree; ENSGT00500000045239; -.
DR HOGENOM; CLU_053879_5_3_1; -.
DR InParanoid; Q22460; -.
DR OMA; PEDQDGP; -.
DR OrthoDB; 1136193at2759; -.
DR PhylomeDB; Q22460; -.
DR PRO; PR:Q22460; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000245; Expressed in larva and 3 other tissues.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00884; beta_CA_cladeB; 1.
DR Gene3D; 3.40.1050.10; -; 1.
DR InterPro; IPR045066; Beta_CA_cladeB.
DR InterPro; IPR001765; Carbonic_anhydrase.
DR InterPro; IPR036874; Carbonic_anhydrase_sf.
DR PANTHER; PTHR11002; PTHR11002; 1.
DR Pfam; PF00484; Pro_CA; 1.
DR SMART; SM00947; Pro_CA; 1.
DR SUPFAM; SSF53056; SSF53056; 1.
PE 3: Inferred from homology;
KW Lyase; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..270
FT /note="Beta carbonic anhydrase 1"
FT /id="PRO_0000374066"
FT BINDING 39
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P45148"
FT BINDING 41
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P45148"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P45148"
FT BINDING 108
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P45148"
SQ SEQUENCE 270 AA; 30686 MW; 5DCA96F0294A7FE1 CRC64;
MNKILRGVIQ FRNTIRKDLV KQFEEIKNNP SPTAVMFTCM DSRMLPTRFT QSQVGDMFVV
RNAGNMIPDA PNYGAFSEVS VNTEPAALEL AVKRGGIRHI VVCGHSDCKA INTLYGLHQC
PKNFDVTSPM DHWVRRNGFA SVKRLNERLH RGPSSMKFES EVAPSQSFDA IIDPMDTLAM
EDKLSQINVL QQLINICSHE FLKEYLESGR LHIHGMWFDI YKGEDYLFSK DKKRFVVIDE
KTVTDLLAEL NARYPVPEDQ DGPVAFAKSN
