RSH3B_MOUSE
ID RSH3B_MOUSE Reviewed; 389 AA.
AC Q9DA80;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Radial spoke head protein 3 homolog B;
DE AltName: Full=A-kinase anchor protein RSPH3B;
DE AltName: Full=Radial spoke head-like protein 2B;
GN Name=Rsph3b; Synonyms=Rshl2, Rshl2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Functions as a protein kinase A-anchoring protein that
CC scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a
CC point of convergence for MAPK and PKA signaling in cilia (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with phosphorylated MAPK1. Interacts with MEK1.
CC Interacts with PKA regulatory subunits PRKAR1A and PRKAR1B (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:P12759}.
CC -!- SIMILARITY: Belongs to the flagellar radial spoke RSP3 family.
CC {ECO:0000305}.
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DR EMBL; AK006083; BAB24400.1; -; mRNA.
DR EMBL; AK076872; BAC36515.1; -; mRNA.
DR EMBL; AK161285; BAE36294.1; -; mRNA.
DR CCDS; CCDS57044.1; -.
DR RefSeq; NP_001077414.1; NM_001083945.1.
DR AlphaFoldDB; Q9DA80; -.
DR SMR; Q9DA80; -.
DR BioGRID; 781945; 1.
DR STRING; 10090.ENSMUSP00000024572; -.
DR iPTMnet; Q9DA80; -.
DR PhosphoSitePlus; Q9DA80; -.
DR MaxQB; Q9DA80; -.
DR PaxDb; Q9DA80; -.
DR PRIDE; Q9DA80; -.
DR ProteomicsDB; 261005; -.
DR Ensembl; ENSMUST00000024572; ENSMUSP00000024572; ENSMUSG00000023806.
DR GeneID; 100037282; -.
DR KEGG; mmu:100037282; -.
DR UCSC; uc008ahy.1; mouse.
DR CTD; 100037282; -.
DR MGI; MGI:3630308; Rsph3b.
DR VEuPathDB; HostDB:ENSMUSG00000023806; -.
DR eggNOG; ENOG502QQSZ; Eukaryota.
DR GeneTree; ENSGT00390000004172; -.
DR HOGENOM; CLU_036980_4_0_1; -.
DR InParanoid; Q9DA80; -.
DR OMA; FFPWLMD; -.
DR OrthoDB; 955313at2759; -.
DR PhylomeDB; Q9DA80; -.
DR TreeFam; TF324184; -.
DR BioGRID-ORCS; 100037282; 5 hits in 39 CRISPR screens.
DR ChiTaRS; Rsph3b; mouse.
DR PRO; PR:Q9DA80; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9DA80; protein.
DR Bgee; ENSMUSG00000023806; Expressed in right kidney and 156 other tissues.
DR ExpressionAtlas; Q9DA80; baseline and differential.
DR Genevisible; Q9DA80; MM.
DR GO; GO:0005929; C:cilium; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR InterPro; IPR009290; Radial_spoke_3.
DR PANTHER; PTHR21648; PTHR21648; 1.
DR Pfam; PF06098; Radial_spoke_3; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..389
FT /note="Radial spoke head protein 3 homolog B"
FT /id="PRO_0000313743"
FT REGION 63..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 206..242
FT /evidence="ECO:0000255"
FT COMPBIAS 87..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 143
FT /note="Phosphothreonine; by MAPK1"
FT /evidence="ECO:0000250"
SQ SEQUENCE 389 AA; 45168 MW; 764D33372F4D9B79 CRC64;
MTDRNPRTAE ASGLYTYSSR PRAVACQRRR HRDSILQPVE EPMSYGNIMY DRRVIRGNTY
ALPTGQVPGQ PDPLELQRQQ QARRRALARK RAQEQLKPRT PEPVEGRKHV DIQTELYLEE
IADRIVEVDM ECQTDAFLDR PPTPLFIPAK TGKDVATQIL GGELFDFDLE VKPMLEVLVG
KTIEQSLLEV MEEEELANLR ARQYAYEEIR NVELAEVQRL EEQERRHREE KERRKKQQWE
IVHKRNETLQ KISALIFARQ YLANLLPSVF DKLRNSGFFY DPIERDIEVG FLPWLMNEVE
KSMEHSMVGR TVLDMLIRDV VERRINDYEH KEAMPPGQKT NVINGPNTVT DPSVTTLHTQ
KPVLDRVSSQ PAPSQERKPV EEGGHLMAE
