RSLAB_HUMAN
ID RSLAB_HUMAN Reviewed; 203 AA.
AC Q96S79; B3KV31;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Ras-like protein family member 10B;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
DE AltName: Full=Ras-like protein VTS58635;
DE AltName: Full=Ras-related protein 17;
DE Short=RRP17;
DE Flags: Precursor;
GN Name=RASL10B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hayashi A., Sato S., Kasama Y., Furuya T., Miyajima N., Saito T.;
RT "Identification of a new member of GTP-binding protein family by virtual
RT transcribed sequence (VTS) approach.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=17984325; DOI=10.1083/jcb.200707101;
RA Rybkin I.I., Kim M.S., Bezprozvannaya S., Qi X., Richardson J.A.,
RA Plato C.F., Hill J.A., Bassel-Duby R., Olson E.N.;
RT "Regulation of atrial natriuretic peptide secretion by a novel Ras-like
RT protein.";
RL J. Cell Biol. 179:527-537(2007).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] MET-52.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May facilitate the release of atrial natriuretic peptide by
CC cardiomyocytes and hence play a role in the regulation of arterial
CC pressure. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P01116};
CC -!- SUBUNIT: Interacts with CADPS. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96S79; P45984: MAPK9; NbExp=3; IntAct=EBI-3919507, EBI-713568;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle and, at
CC much lower levels, in heart, brain and pancreas.
CC {ECO:0000269|PubMed:17984325}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000305}.
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DR EMBL; AB047296; BAB60894.1; -; mRNA.
DR EMBL; AK122652; BAG53643.1; -; mRNA.
DR EMBL; BC041133; AAH41133.1; -; mRNA.
DR CCDS; CCDS11297.1; -.
DR RefSeq; NP_201572.1; NM_033315.3.
DR RefSeq; XP_016880790.1; XM_017025301.1.
DR AlphaFoldDB; Q96S79; -.
DR SMR; Q96S79; -.
DR BioGRID; 124852; 61.
DR IntAct; Q96S79; 23.
DR MINT; Q96S79; -.
DR STRING; 9606.ENSP00000474230; -.
DR iPTMnet; Q96S79; -.
DR PhosphoSitePlus; Q96S79; -.
DR BioMuta; RASL10B; -.
DR DMDM; 74732702; -.
DR MassIVE; Q96S79; -.
DR PaxDb; Q96S79; -.
DR PeptideAtlas; Q96S79; -.
DR PRIDE; Q96S79; -.
DR ProteomicsDB; 78082; -.
DR Antibodypedia; 73077; 72 antibodies from 18 providers.
DR DNASU; 91608; -.
DR Ensembl; ENST00000603017.2; ENSP00000474230.1; ENSG00000270885.2.
DR GeneID; 91608; -.
DR KEGG; hsa:91608; -.
DR MANE-Select; ENST00000603017.2; ENSP00000474230.1; NM_033315.4; NP_201572.1.
DR UCSC; uc002hju.4; human.
DR CTD; 91608; -.
DR DisGeNET; 91608; -.
DR GeneCards; RASL10B; -.
DR HGNC; HGNC:30295; RASL10B.
DR HPA; ENSG00000270885; Tissue enhanced (brain, skeletal muscle).
DR MIM; 612128; gene.
DR neXtProt; NX_Q96S79; -.
DR OpenTargets; ENSG00000270885; -.
DR PharmGKB; PA134936888; -.
DR VEuPathDB; HostDB:ENSG00000270885; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000160764; -.
DR HOGENOM; CLU_041217_9_3_1; -.
DR InParanoid; Q96S79; -.
DR OMA; WPAVCES; -.
DR OrthoDB; 1283500at2759; -.
DR PhylomeDB; Q96S79; -.
DR TreeFam; TF325043; -.
DR PathwayCommons; Q96S79; -.
DR SignaLink; Q96S79; -.
DR BioGRID-ORCS; 91608; 10 hits in 1063 CRISPR screens.
DR GenomeRNAi; 91608; -.
DR Pharos; Q96S79; Tdark.
DR PRO; PR:Q96S79; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96S79; protein.
DR Bgee; ENSG00000270885; Expressed in vena cava and 152 other tissues.
DR Genevisible; Q96S79; HS.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
DR GO; GO:0003050; P:regulation of systemic arterial blood pressure by atrial natriuretic peptide; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51421; RAS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; GTP-binding; Hydrolase; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..200
FT /note="Ras-like protein family member 10B"
FT /id="PRO_0000280800"
FT PROPEP 201..203
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000281362"
FT REGION 1..203
FT /note="Small GTPase-like"
FT MOTIF 33..42
FT /note="Effector region"
FT BINDING 11..18
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 59..62
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 128..131
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 200
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 200
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
FT VARIANT 52
FT /note="V -> M (in a breast cancer sample; somatic mutation;
FT dbSNP:rs781851443)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036309"
FT CONFLICT 109
FT /note="Q -> R (in Ref. 2; BAG53643)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 203 AA; 23229 MW; A9771A883B30A8BC CRC64;
MVSTYRVAVL GARGVGKSAI VRQFLYNEFS EVCVPTTARR LYLPAVVMNG HVHDLQILDF
PPISAFPVNT LQEWADTCCR GLRSVHAYIL VYDICCFDSF EYVKTIRQQI LETRVIGTSE
TPIIIVGNKR DLQRGRVIPR WNVSHLVRKT WKCGYVECSA KYNWHILLLF SELLKSVGCA
RCKHVHAALR FQGALRRNRC AIM
