ABCCD_DICDI
ID ABCCD_DICDI Reviewed; 1350 AA.
AC Q54V86; Q8T6G7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=ABC transporter C family member 13;
DE AltName: Full=ABC transporter ABCC.13;
GN Name=abcC13; ORFNames=DDB_G0280539;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 682-1350, AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000037; EAL67071.1; -; Genomic_DNA.
DR EMBL; AF474345; AAL85716.1; -; Genomic_DNA.
DR RefSeq; XP_641045.1; XM_635953.1.
DR AlphaFoldDB; Q54V86; -.
DR SMR; Q54V86; -.
DR STRING; 44689.DDB0215342; -.
DR PaxDb; Q54V86; -.
DR PRIDE; Q54V86; -.
DR EnsemblProtists; EAL67071; EAL67071; DDB_G0280539.
DR GeneID; 8622603; -.
DR KEGG; ddi:DDB_G0280539; -.
DR dictyBase; DDB_G0280539; abcC13.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_1_1; -.
DR InParanoid; Q54V86; -.
DR OMA; IFICKIS; -.
DR PhylomeDB; Q54V86; -.
DR PRO; PR:Q54V86; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1350
FT /note="ABC transporter C family member 13"
FT /id="PRO_0000363857"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 887..907
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 909..929
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1003..1023
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1029..1049
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 107..390
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 473..693
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 774..1061
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1103..1337
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 462..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 505..512
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1137..1144
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 704
FT /note="Q -> H (in Ref. 2; AAL85716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1350 AA; 154170 MW; 88431B74E679D0E2 CRC64;
MFERINKIKK KIKEKLSYSI LKDEKIDYYN LPCPEESASF LSKLTFSWTQ RMLMTGYFRG
PIQMSDICDL PDDVKVQKTN PILDDIDFGN SKWPLLKFIY TNFVTKNKKS IFIVILCAIF
SILSPLCLKY FIKYIQLSKN EKTFLTGLGY CVLLFVGTFS YTLSQQFLYW FGMRTSLHVR
GALSQRIYEK MLKLSSSGGK KYSSGSIMNL ISTDIGLFAD FFWIGHLEII IFPIQITALL
ALLCWIVGWS GLVGFGVMII SLPINTFFGS KMSKNLMLSL GYSDTRCNLT SEFINGIRFL
KLYAWEKLFL DRIEEQRRLQ LKYLYRRVIF AIFEKMLSQT TNAVVLVSTF SVYSINNEIE
LSVAFTAITI FVNLRQPIMR LPEAIHNLLG LIPSAKRVES FLQLSEIQTQ PFINFNNKSI
NDDILIDNGT FNWNQDNDDY ITNNGDNNNN NNKNEIKKRL IEKSEEEYET TTTTTDDNNN
NNYESYLLNN INFKAPAGKL TIICGVVGSG KTSLVSGLIG EIYKVSGRVN TPNKISFTTQ
QSFLLSTSLR ENILFGNEMN LERYKKVIEA CCLAPDLLQL AAKDLTEIGE RGINLSGGQK
QRISLARALY ANSDCYILDE PLSAVDPEVA THLFNHCIQG MMNDKTRILV THQLQFIPSA
DHIVVVDNGK LVQGTYSELK SKGIDFESIM KTKKLNIDNQ QQQQQQQQHD ENEIIDENPM
KKSNSLIESN KLINIDEIIS DKHDSNLIEK AKLLVKEDKS EGAIGLHVYR EYFKHGSSTF
FFIATCVVYF FSQAIFQMTD FWLSTWSQHK LQGKSDSFYI FYYIIFIGLF IVTLVIRYFM
LAHVTFSASK NLHTSLLNSV GFASCQFFDT NPSGRILNRF SKDIAEIDLL LYDLFSDVLY
CGSTVVFAIC VMIYISPLIS LPFLVLIIVY NIIKNIYAVS SRDLKRYESI TRSPIFSLLQ
ETFNGLVTIR SYQQQNRFIS MMQDHININL RLFYYSFSIH RWIGVRLEFI SALVVFLTAF
FSLFNSNAGF SVLSVTTAIG MCTYLNWAVR QFVELEVKMN SVERIESYIN TPKEGNRFTI
DNEEEGEENM INLNEKWPSK GEIEFRDVEI RYRPTSEPSL KNLSFKINSN DHIGIVGRTG
AGKSTVGISL FRMVECSKGS ILIDGIDISK IGLHDLRSSL GIVPQDPFIF SGTIRLNIDP
FNKYTDSEIW VALEKVKLKS TISSMPLKLE TMIEEGGDGL SFGQKQLLCL SRTILKNSKV
VLMDEATSGI DYVTGDLIKQ TLLENFNDCT MLTIAHRLDT IIDSTKIAVV DKGELIEYDT
PINLINTKNS KFSKLVKYQT DFHKENEKNF
