RSLBA_MOUSE
ID RSLBA_MOUSE Reviewed; 242 AA.
AC Q6IMB1; Q148R6;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Ras-like protein family member 11A;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN Name=Rasl11a {ECO:0000312|MGI:MGI:1916145};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAE43176.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE43176.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAE43176.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI18010.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305, ECO:0000312|EMBL:DAA02248.1}
RP IDENTIFICATION (ISOFORM 1).
RX PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA Verjovski-Almeida S., Reis E.M.;
RT "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT differentially expressed in prostate tumors.";
RL Biochem. Biophys. Res. Commun. 316:618-627(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH UBTF.
RX PubMed=20168301; DOI=10.1038/emboj.2010.16;
RA Pistoni M., Verrecchia A., Doni M., Guccione E., Amati B.;
RT "Chromatin association and regulation of rDNA transcription by the Ras-
RT family protein RasL11a.";
RL EMBO J. 29:1215-1224(2010).
CC -!- FUNCTION: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF
CC and positively regulates RNA polymerase I transcription.
CC {ECO:0000269|PubMed:20168301}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P01116};
CC -!- SUBUNIT: Interacts with UBF/UBTF. {ECO:0000269|PubMed:20168301}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:20168301}.
CC Note=Associates with rDNA transcription unit throughout the cell cycle.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:16141072};
CC IsoId=Q6IMB1-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15489334};
CC IsoId=Q6IMB1-2; Sequence=VSP_052584;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000255}.
CC -!- CAUTION: Although highly related to the Ras family, lacks the conserved
CC prenylation motif at the C-terminus, which serves to target Ras
CC proteins to membrane compartments. {ECO:0000305}.
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DR EMBL; AK004371; BAE43176.1; -; mRNA.
DR EMBL; AC124828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118009; AAI18010.1; -; mRNA.
DR EMBL; BK001706; DAA02248.1; -; mRNA.
DR CCDS; CCDS39396.1; -. [Q6IMB1-1]
DR RefSeq; NP_081140.1; NM_026864.1. [Q6IMB1-1]
DR AlphaFoldDB; Q6IMB1; -.
DR SMR; Q6IMB1; -.
DR IntAct; Q6IMB1; 4.
DR MINT; Q6IMB1; -.
DR STRING; 10090.ENSMUSP00000031646; -.
DR iPTMnet; Q6IMB1; -.
DR PhosphoSitePlus; Q6IMB1; -.
DR MaxQB; Q6IMB1; -.
DR PaxDb; Q6IMB1; -.
DR PRIDE; Q6IMB1; -.
DR ProteomicsDB; 260997; -. [Q6IMB1-1]
DR ProteomicsDB; 260998; -. [Q6IMB1-2]
DR Antibodypedia; 62567; 28 antibodies from 11 providers.
DR Ensembl; ENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641. [Q6IMB1-1]
DR GeneID; 68895; -.
DR KEGG; mmu:68895; -.
DR UCSC; uc009anm.1; mouse. [Q6IMB1-1]
DR CTD; 387496; -.
DR MGI; MGI:1916145; Rasl11a.
DR VEuPathDB; HostDB:ENSMUSG00000029641; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000161208; -.
DR HOGENOM; CLU_041217_9_7_1; -.
DR InParanoid; Q6IMB1; -.
DR OMA; TMSGHCL; -.
DR OrthoDB; 1384728at2759; -.
DR PhylomeDB; Q6IMB1; -.
DR TreeFam; TF318030; -.
DR BioGRID-ORCS; 68895; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q6IMB1; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6IMB1; protein.
DR Bgee; ENSMUSG00000029641; Expressed in renal corpuscle and 102 other tissues.
DR Genevisible; Q6IMB1; MM.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IDA:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51421; RAS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; GTP-binding; Hydrolase; Nucleotide-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..242
FT /note="Ras-like protein family member 11A"
FT /id="PRO_0000308361"
FT REGION 17..241
FT /note="Small GTPase-like"
FT BINDING 34..41
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96A58"
FT BINDING 81..88
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96A58"
FT BINDING 147..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96A58"
FT VAR_SEQ 1..42
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_052584"
SQ SEQUENCE 242 AA; 27067 MW; C2A97D12904DA251 CRC64;
MRPLTMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGCVGK SAMIVRFLTK RFIGDYEPNT
GKLYSRLVYV EGDQLSLQIQ DTPGGIQAQD SLSQMVDSLT KSVHWAEGFL LVYSITDYES
YQSIRPLYQH IRKVHPDGKA PIFIVGNKGD LLHARQVQTH EGLQLANELG SLFLEISTSE
NYEDVCDVFQ HLCKEVIKVH RLGGERRRAS VIPRPRSPNM QDLKRRFRQA LSSKAKASSA
LG
