ID   RSLBB_BOVIN             Reviewed;         248 AA.
AC   Q5E9J3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Ras-like protein family member 11B;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN   Name=RASL11B {ECO:0000312|EMBL:AAX08944.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAX08944.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2] {ECO:0000312|EMBL:AAI42346.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI42346.1};
RC   TISSUE=Fetal medulla {ECO:0000312|EMBL:AAI42346.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P01116};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000255}.
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DR   EMBL; BT020927; AAX08944.1; -; mRNA.
DR   EMBL; BT029844; ABM21552.1; -; mRNA.
DR   EMBL; BC142345; AAI42346.1; -; mRNA.
DR   RefSeq; NP_001015635.1; NM_001015635.2.
DR   AlphaFoldDB; Q5E9J3; -.
DR   SMR; Q5E9J3; -.
DR   STRING; 9913.ENSBTAP00000027515; -.
DR   PaxDb; Q5E9J3; -.
DR   Ensembl; ENSBTAT00000027515; ENSBTAP00000027515; ENSBTAG00000020647.
DR   GeneID; 528446; -.
DR   KEGG; bta:528446; -.
DR   CTD; 65997; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020647; -.
DR   VGNC; VGNC:33755; RASL11B.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000158643; -.
DR   HOGENOM; CLU_041217_9_7_1; -.
DR   InParanoid; Q5E9J3; -.
DR   OMA; KEVEPQH; -.
DR   OrthoDB; 1384728at2759; -.
DR   TreeFam; TF318030; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000020647; Expressed in cumulus cell and 101 other tissues.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:Ensembl.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Ras-like protein family member 11B"
FT                   /id="PRO_0000308364"
FT   REGION          29..246
FT                   /note="Small GTPase-like"
FT   REGION          205..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         40..47
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         87..91
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         152..155
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
SQ   SEQUENCE   248 AA;  27400 MW;  CCFFF9700165E11F CRC64;
     MRLIQNMCTI AEYPAPGSAA AADCCLGAAG RRLVKIAVVG ASGVGKTALV VRFLTKRFIG
     DYERNAGNLY TRQVQIEGET LAIQVQDTPG IQVHENGLSC TEQLNRCIRW ADAVVIVFSI
     TDYKSYELTS QLHQHVQQLH LGTRLPVVVV ANKADLLHIK QVDPQLGLQL ASMLGCSFYE
     VSVSENDNDV YNAFHVLCKE VSHKQQPSGT PEKRRTSLIP RPKSPNMQDL KRRFKQALSA
     KVRTVTSV