ID   RSLBB_DANRE             Reviewed;         244 AA.
AC   Q6P0U3; Q001T7; Q803I5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Ras-like protein family member 11B;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN   Name=rasl11b {ECO:0000312|ZFIN:ZDB-GENE-040426-793};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:ABI97979.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pezeron G., Lambert G., Dickmeis T., Strahle U., Rosa F., Mourrain P.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:ABI97979.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB {ECO:0000312|EMBL:AAH44471.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305, ECO:0000312|EMBL:DAA02246.1}
RP   IDENTIFICATION.
RX   PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA   Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA   Verjovski-Almeida S., Reis E.M.;
RT   "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT   differentially expressed in prostate tumors.";
RL   Biochem. Biophys. Res. Commun. 316:618-627(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P01116};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ983377; ABI97979.1; -; mRNA.
DR   EMBL; BC044471; AAH44471.1; -; mRNA.
DR   EMBL; BC065446; AAH65446.1; -; mRNA.
DR   EMBL; BK001704; DAA02246.1; -; mRNA.
DR   RefSeq; NP_956434.1; NM_200140.1.
DR   AlphaFoldDB; Q6P0U3; -.
DR   SMR; Q6P0U3; -.
DR   STRING; 7955.ENSDARP00000003188; -.
DR   PaxDb; Q6P0U3; -.
DR   PRIDE; Q6P0U3; -.
DR   Ensembl; ENSDART00000015755; ENSDARP00000003188; ENSDARG00000015611.
DR   GeneID; 393109; -.
DR   KEGG; dre:393109; -.
DR   CTD; 65997; -.
DR   ZFIN; ZDB-GENE-040426-793; rasl11b.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000158643; -.
DR   HOGENOM; CLU_041217_9_7_1; -.
DR   InParanoid; Q6P0U3; -.
DR   OMA; KEVEPQH; -.
DR   OrthoDB; 1384728at2759; -.
DR   PhylomeDB; Q6P0U3; -.
DR   TreeFam; TF318030; -.
DR   PRO; PR:Q6P0U3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000015611; Expressed in axis (Danio) and 48 other tissues.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0048382; P:mesendoderm development; IGI:ZFIN.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..244
FT                   /note="Ras-like protein family member 11B"
FT                   /id="PRO_0000308368"
FT   REGION          19..242
FT                   /note="Small GTPase-like"
FT   REGION          200..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         30..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         77..81
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         142..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   CONFLICT        203
FT                   /note="T -> A (in Ref. 1; ABI97979)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        222
FT                   /note="N -> D (in Ref. 2; AAH44471)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   244 AA;  26974 MW;  EDEFAA8FAC62C37F CRC64;
     MRLIQNMSTI AEYPSADCPS SRVIKIAVIG GSGVGKTALV VRFLTKRFIG DYERNVGNLY
     SREVQIDGEQ VAIQVQDTPG VQVNANGLSC TDHVSRSIQW ADAVVMVYSV TDRKSFDLIG
     QLHQLVTRTH SDRSIPIILV ANKADLLHVR RVDAQEGPVL SSALSCSFYE VSASEDYNQV
     HSAFHRLCVD LAKLQPQTPI NATSSVTEKK RSPLIPRPKS PNMQDLKRRF KQVLSAKVRT
     VTSV