RSLBB_MOUSE
ID RSLBB_MOUSE Reviewed; 247 AA.
AC Q922H7; Q9D0S0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Ras-like protein family member 11B;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN Name=Rasl11b {ECO:0000312|EMBL:AAH08101.1, ECO:0000312|MGI:MGI:1916189};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB23353.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB23353.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAB23353.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH08101.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH83068.1}, and
RC FVB/N {ECO:0000312|EMBL:AAH08101.1};
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH08101.1}, and
RC Olfactory epithelium {ECO:0000312|EMBL:AAH83068.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA02249.1}
RP IDENTIFICATION (ISOFORM 1).
RX PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA Verjovski-Almeida S., Reis E.M.;
RT "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT differentially expressed in prostate tumors.";
RL Biochem. Biophys. Res. Commun. 316:618-627(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P01116};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:15489334};
CC IsoId=Q922H7-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16141072};
CC IsoId=Q922H7-2; Sequence=VSP_052585, VSP_052586;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000255}.
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DR EMBL; AK004534; BAB23353.1; -; mRNA.
DR EMBL; BC008101; AAH08101.1; -; mRNA.
DR EMBL; BC083068; AAH83068.1; -; mRNA.
DR EMBL; BK001707; DAA02249.1; -; mRNA.
DR CCDS; CCDS39113.1; -. [Q922H7-1]
DR RefSeq; NP_081154.1; NM_026878.1. [Q922H7-1]
DR AlphaFoldDB; Q922H7; -.
DR SMR; Q922H7; -.
DR STRING; 10090.ENSMUSP00000053389; -.
DR iPTMnet; Q922H7; -.
DR PhosphoSitePlus; Q922H7; -.
DR PaxDb; Q922H7; -.
DR PRIDE; Q922H7; -.
DR ProteomicsDB; 261007; -. [Q922H7-1]
DR ProteomicsDB; 261008; -. [Q922H7-2]
DR Antibodypedia; 23900; 97 antibodies from 25 providers.
DR Ensembl; ENSMUST00000051937; ENSMUSP00000053389; ENSMUSG00000049907. [Q922H7-1]
DR GeneID; 68939; -.
DR KEGG; mmu:68939; -.
DR UCSC; uc008xtj.1; mouse. [Q922H7-1]
DR CTD; 65997; -.
DR MGI; MGI:1916189; Rasl11b.
DR VEuPathDB; HostDB:ENSMUSG00000049907; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000158643; -.
DR HOGENOM; CLU_041217_9_7_1; -.
DR InParanoid; Q922H7; -.
DR OMA; KEVEPQH; -.
DR OrthoDB; 1384728at2759; -.
DR PhylomeDB; Q922H7; -.
DR TreeFam; TF318030; -.
DR BioGRID-ORCS; 68939; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Rasl11b; mouse.
DR PRO; PR:Q922H7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q922H7; protein.
DR Bgee; ENSMUSG00000049907; Expressed in urinary bladder urothelium and 258 other tissues.
DR Genevisible; Q922H7; MM.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IPI:MGI.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51421; RAS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; GTP-binding; Hydrolase; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..247
FT /note="Ras-like protein family member 11B"
FT /id="PRO_0000308366"
FT REGION 28..245
FT /note="Small GTPase-like"
FT REGION 202..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 39..46
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96A58"
FT BINDING 86..93
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96A58"
FT BINDING 151..154
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96A58"
FT VAR_SEQ 1..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052585"
FT VAR_SEQ 60..90
FT /note="DYERNAGNLYTRQVHIEGETLAIQVQDTPGI -> MKGSFELRDVLWPELSA
FT VPTASCSPCSPSSP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052586"
FT CONFLICT 224
FT /note="P -> L (in Ref. 1; BAB23353)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 27362 MW; 58B70AF005718538 CRC64;
MRLIQNMCTI AEYPAPGSTA ADCCLGAAGR RLVKIAVVGA SGVGKTALVV RFLTKRFIGD
YERNAGNLYT RQVHIEGETL AIQVQDTPGI QVHENGLSCS EQLNRCIRWA DAVVLVFSIT
DHKSYELISQ LHQHVQQLHP GTRLPVVLVA NKADLLHVKQ VDPQLGLQLA SMLGCSFYEV
SVSENYNDVY NAFHVLCKEV SPKQQPSSTP EKRRTSLIPR PKSPNMQDLK RRFKQALSAK
VRTVTSV
