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RSLBB_RAT
ID   RSLBB_RAT               Reviewed;         247 AA.
AC   Q6IMA7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Ras-like protein family member 11B;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN   Name=Rasl11b {ECO:0000312|RGD:1303099};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000312|EMBL:AAH83755.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway {ECO:0000312|EMBL:AAH83755.1};
RC   TISSUE=Heart {ECO:0000312|EMBL:AAH83755.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:DAA02252.1}
RP   IDENTIFICATION.
RX   PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA   Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA   Verjovski-Almeida S., Reis E.M.;
RT   "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT   differentially expressed in prostate tumors.";
RL   Biochem. Biophys. Res. Commun. 316:618-627(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P01116};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000255}.
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DR   EMBL; AC114452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC083755; AAH83755.1; -; mRNA.
DR   EMBL; BK001710; DAA02252.1; -; mRNA.
DR   RefSeq; NP_001002830.1; NM_001002830.2.
DR   AlphaFoldDB; Q6IMA7; -.
DR   SMR; Q6IMA7; -.
DR   STRING; 10116.ENSRNOP00000002869; -.
DR   PhosphoSitePlus; Q6IMA7; -.
DR   PaxDb; Q6IMA7; -.
DR   PRIDE; Q6IMA7; -.
DR   Ensembl; ENSRNOT00000002869; ENSRNOP00000002869; ENSRNOG00000002097.
DR   GeneID; 305302; -.
DR   KEGG; rno:305302; -.
DR   UCSC; RGD:1303099; rat.
DR   CTD; 65997; -.
DR   RGD; 1303099; Rasl11b.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000158643; -.
DR   HOGENOM; CLU_041217_9_7_1; -.
DR   InParanoid; Q6IMA7; -.
DR   OMA; KEVEPQH; -.
DR   OrthoDB; 1384728at2759; -.
DR   PhylomeDB; Q6IMA7; -.
DR   TreeFam; TF318030; -.
DR   PRO; PR:Q6IMA7; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000002097; Expressed in frontal cortex and 19 other tissues.
DR   Genevisible; Q6IMA7; RN.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; ISO:RGD.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Ras-like protein family member 11B"
FT                   /id="PRO_0000308367"
FT   REGION          28..245
FT                   /note="Small GTPase-like"
FT   REGION          204..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         39..46
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         86..93
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         151..154
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
SQ   SEQUENCE   247 AA;  27291 MW;  CBC64C78FE4CE72F CRC64;
     MRLIQNMCTI AEYPAPGSTA ADCCLGAAGR RLVKIAVVGA SGVGKTALVV RFLTKRFIGD
     YERNAGNLYT RQVHIEGETL AIQVQDTPGI QVHENGLSCN EQLNRCIRWA DAVVIVFSIT
     DHKSYELISQ LHQHVQQLHP GTRLPVVVVA NKADLLHVKQ VDPQLGLQLA SMLGCSFYEV
     SVSENYNDVY SAFHVLCKEV SPKQQASGTP EKRRTSLIPR PKSPNMQDLK RRFKQALSAK
     VRTVTSV
 
 
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