ID   RSLBB_XENLA             Reviewed;         248 AA.
AC   Q8AVS6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Ras-like protein family member 11B;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN   Name=rasl11b {ECO:0000303|PubMed:15033445};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH41294.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH41294.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA02255.1}
RP   IDENTIFICATION.
RX   PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA   Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA   Verjovski-Almeida S., Reis E.M.;
RT   "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT   differentially expressed in prostate tumors.";
RL   Biochem. Biophys. Res. Commun. 316:618-627(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P01116};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000255}.
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DR   EMBL; BC041294; AAH41294.1; -; mRNA.
DR   EMBL; BK001713; DAA02255.1; -; mRNA.
DR   RefSeq; NP_001079395.1; NM_001085926.1.
DR   AlphaFoldDB; Q8AVS6; -.
DR   SMR; Q8AVS6; -.
DR   DNASU; 379082; -.
DR   GeneID; 379082; -.
DR   KEGG; xla:379082; -.
DR   CTD; 379082; -.
DR   Xenbase; XB-GENE-866025; rasl11b.L.
DR   OMA; KEVEPQH; -.
DR   OrthoDB; 1384728at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379082; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Ras-like protein family member 11B"
FT                   /id="PRO_0000308369"
FT   REGION          30..248
FT                   /note="Small GTPase-like"
FT   REGION          206..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         41..48
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         88..99
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
FT   BINDING         153..156
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A58"
SQ   SEQUENCE   248 AA;  27613 MW;  3F35696A5ED2C7F7 CRC64;
     MRLIQNMCTI TEYPPATNTD CGSSSSAGTA SSRVIKIAVV GGSGVGKTAL VVRFLTKRFI
     GDYERNAGNL YSRQVQIDGT NLAIQVQDTP GVQINEQNLE SNEQLNKSLR WADAVVIVFS
     ITDCKSFDLI SHLHRHARQL HPDNRIPIVI VANKADLLHL KQVEPQHGLQ LANMLGCTFY
     EVSVSENYND VYNAFQVLCK EISKQQNTGT SERRKNSIIP RPKSPNMQDL KRRFKQALSS
     KVRTATSV